Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity

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Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity

Volz, Erik (author): Imperial College London

Hill, Verity (author): University of Edinburgh

McCrone, John T (author): University of Edinburgh

Price, Anna (author): Cardiff Metropolitan University

Jorgensen, David (author)

O'Toole, Áine (author): University of Edinburgh

Southgate, Joel (author): Cardiff Metropolitan University

Johnson, Robert (author)

Jackson, Ben (author): University of Edinburgh

Nascimento, Fabricia F (author): Imperial College London

Rey, Sara M (author): Public Health Wales

Nicholls, Samuel M (author): Birmingham City University

Colquhoun, Rachel M (author)

da Silva Filipe, Ana (author): University of Glasgow

Shepherd, James (author): University of Glasgow

Pascall, David J (author)

Shah, Rajiv (author)

Jesudason, Natasha (author)

Li, Kathy (author)

Jarrett, Ruth (author)

Pacchiarini, Nicole (author): Public Health Wales

Bull, Matthew (author)

Geidelberg, Lily (author)

Siveroni, Igor (author)

Goodfellow, Ian (author): University of Cambridge

Loman, Nicholas J (author): Birmingham City University

Pybus, Oliver G (author): University of Oxford

Robertson, David L (author): University of Glasgow

Thomson, Emma C (author)

Rambaut, Andrew (author)

Connor, Thomas R (author): Cardiff Metropolitan University

Balcazar Lopez, Carlos Enrique (creator_code:cre_t): Lund University,Lunds universitet,Funktionell bröstcancergenomik,Forskargrupper vid Lunds universitet,Bröst/ovarialcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Functional Breast Cancer Genomics,Lund University Research Groups,Breast/ovarian cancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,University of Edinburgh

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(creator_code:org_t)

Elsevier BV, 2021
2021
English.
In: Cell. - : Elsevier BV. - 1097-4172 .- 0092-8674. ; 184:1, s. 11-75

Related links:: http://dx.doi.org/10...; show more...; http://www.cell.com/...; https://lup.lub.lu.s...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)

Keyword

Amino Acid Substitution
Aspartic Acid/analysis
COVID-19/epidemiology
Genome, Viral
Glycine/analysis
Humans
Mutation
SARS-CoV-2/genetics
Spike Glycoprotein, Coronavirus/genetics
United Kingdom/epidemiology
Virulence
Whole Genome Sequencing

Publication and Content Type

art (subject category)
ref (subject category)

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Infectious Medic ...

Articles in the publication: Cell

By the university: Lund University

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