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Serum levels of per...
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Kvist, LinusLund University,Lunds universitet,Molekylärgenetisk reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Molecular genetic reproductive medicine, Malmö,Lund University Research Groups
(author)
Serum levels of perfluorinated compounds and sperm Y:X chromosome ratio in two European populations and in Inuit from Greenland.
- Article/chapterEnglish2012
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Elsevier BV,2012
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LIBRIS-ID:oai:lup.lub.lu.se:b6fd1212-234c-4398-b6ad-5464294a7b4c
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https://lup.lub.lu.se/record/3160983URI
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https://doi.org/10.1016/j.reprotox.2012.09.007DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
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This study investigated whether perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS), which exhibit reproductive toxicity in experimental animals, affect sperm sex chromosome ratio. The Y:X ratio was determined by fluorescence in situ hybridization. Serum concentrations of PFOA and PFOS were measured in 607 men from Greenland, Poland and Ukraine using liquid chromatography-tandem mass spectrometry. Data was analyzed by linear and nonlinear regression. We observed no associations between PFOA and Y:X ratio (p=0.845 in a linear model, p=0.296 in a nonlinear model). A positive nonlinear association between PFOS and Y:X ratio was observed (p=0.016), with no association in a linear model (p=0.118). Analyzing the populations separately, a negative trend between categorized PFOS exposure and Y:X ratio was observed for the Inuit (B=-0.002, p=0.044). In conclusion, there was a negative trend between Y:X ratio and PFOS in the Inuit, while there was no association between PFOA and the Y:X ratio in adult men.
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Giwercman, YvonneLund University,Lunds universitet,Molekylärgenetisk reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproduktionsmedicin, Malmö,Molecular genetic reproductive medicine, Malmö,Lund University Research Groups,Reproductive medicine, Malmö(Swepub:lu)kir-ylu
(author)
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Jönsson, Bo ALund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)ymed-bjo
(author)
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Lindh, ChristianLund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)ymed-cli
(author)
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Bonde, Jens-Peter
(author)
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Toft, Gunnar
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Strucinski, Pawel
(author)
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Pedersen, Henning S
(author)
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Zvyezday, Valentyna
(author)
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Giwercman, AleksanderLund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups(Swepub:lu)kir-agi
(author)
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Molekylärgenetisk reproduktionsmedicin, MalmöForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:Reproductive Toxicology: Elsevier BV1873-17080890-6238
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Kvist, Linus
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Toft, Gunnar
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