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Guthrie card methyl...
Guthrie card methylomics identifies temporally stable epialleles that are present at birth in humans
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Beyan, Huriya (author)
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Down, Thomas A. (author)
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Ramagopalan, Sreeram V. (author)
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Uvebrant, Kristina (author)
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- Ramelius, Anita (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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Holland, Michelle L. (author)
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Gemma, Carolina (author)
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Giovannoni, Gavin (author)
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Boehm, Bernhard O. (author)
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Ebers, George C. (author)
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- Lernmark, Åke (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Cilio, Corrado (author)
- Lund University,Lunds universitet,Diabetes - immunovirologi,Forskargrupper vid Lunds universitet,Diabetes - Immunovirology,Lund University Research Groups
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Leslie, R. David (author)
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Rakyan, Vardhman K. (author)
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(creator_code:org_t)
- 2012-08-23
- 2012
- English.
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In: Genome Research. - : Cold Spring Harbor Laboratory. - 1549-5469 .- 1088-9051. ; 22:11, s. 2138-2145
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http://dx.doi.org/10...
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http://genome.cshlp....
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Abstract
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- A major concern in common disease epigenomics is distinguishing causal from consequential epigenetic variation. One means of addressing this issue is to identify the temporal origins of epigenetic variants via longitudinal analyses. However, prospective birth-cohort studies are expensive and time consuming. Here, we report DNA methylomics of archived Guthrie cards for the retrospective longitudinal analyses of in-utero-derived DNA methylation variation. We first validate two methodologies for generating comprehensive DNA methylomes from Guthrie cards. Then, using an integrated epigenomic/genomic analysis of Guthrie cards and follow-up samplings, we identify interindividual DNA methylation variation that is present both at birth and 3 yr later. These findings suggest that disease-relevant epigenetic variation could be detected at birth, i.e., before overt clinical disease. Guthrie card methylomics offers a potentially powerful and cost-effective strategy for studying the dynamics of interindividual epigenomic variation in a range of common human diseases.
Subject headings
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Beyan, Huriya
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Down, Thomas A.
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Ramagopalan, Sre ...
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Uvebrant, Kristi ...
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Ramelius, Anita
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Holland, Michell ...
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show more...
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Gemma, Carolina
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Giovannoni, Gavi ...
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Boehm, Bernhard ...
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Ebers, George C.
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Lernmark, Åke
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Cilio, Corrado
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Leslie, R. David
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Rakyan, Vardhman ...
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
- Articles in the publication
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Genome Research
- By the university
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Lund University