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The Structure and C...
The Structure and Classification of Botulinum Toxins
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- Dong, Min (author)
- Harvard Medical School,Boston Children's Hospital
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- Stenmark, Pål (author)
- Stockholm University,Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine
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Whitcup, Scott M. (editor)
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Hallett, Mark (editor)
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(creator_code:org_t)
- 2019-12-03
- 2021
- English 23 s.
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In: Botulinum Toxin Therapy. - Cham : Springer International Publishing. - 0171-2004. - 9783030663056 ; 263, s. 11-33
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Abstract
Subject headings
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- Botulinum neurotoxins (BoNTs) are a family of bacterial protein toxins produced by various Clostridium species. They are traditionally classified into seven major serotypes (BoNT/A-G). Recent progress in sequencing microbial genomes has led to an ever-growing number of subtypes, chimeric toxins, BoNT-like toxins, and remotely related BoNT homologs, constituting an expanding BoNT superfamily. Recent structural studies of BoNTs, BoNT progenitor toxin complexes, tetanus neurotoxin (TeNT), toxin-receptor complexes, and toxin-substrate complexes have provided mechanistic understandings of toxin functions and the molecular basis for their variations. The growing BoNT superfamily of toxins present a natural repertoire that can be explored to develop novel therapeutic toxins, and the structural understanding of their variations provides a knowledge basis for engineering toxins to improve therapeutic efficacy and expand their clinical applications.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
Publication and Content Type
- kap (subject category)
- ref (subject category)
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