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Thrombospondin-4 me...
Thrombospondin-4 mediates cardiovascular remodelling in angiotensin II-induced hypertension
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- Palao, Teresa (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- Medzikovic, Lejla (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- Rippe, Catarina (author)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine
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- Wanga, Shaynah (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- Al-Mardini, Claudia (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- van Weert, Angela (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- de Vos, Judith (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- van der Wel, Nicole N. (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- van Veen, Henk A. (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- van Bavel, Ed T. (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- Swärd, Karl (author)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine
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- de Waard, Vivian (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- Bakker, Erik NTP (author)
- Academic Medical Center of University of Amsterdam (AMC)
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- English 8 s.
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In: Cardiovascular Pathology. - : Elsevier BV. - 1054-8807. ; 35, s. 12-19
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Abstract
Subject headings
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- Thrombospondin 4 (TSP-4) expression is induced in the heart and vasculature under pathological conditions, including myocardial infarction, myocardial pressure overload, and hypertension. TSP-4 is linked to remodelling processes, where it may affect extracellular matrix protein organization. In previous work, we studied the role of TSP-4 in small arteries during hypertension using Ang II-treated Thrombospondin 4 knockout (Thbs4−/−) mice. We reported increased heart weight, as well as the occurrence of aortic aneurysms in the Ang II-treated Thbs4−/− animals. In the present study, we further characterized the hearts and aortas from these animals. Hypertrophy of cardiomyocytes, together with perivascular fibrosis and inflammation was observed in the Ang II-treated Thbs4−/− hearts. In the aortas, an increase in the aortic wall cross-sectional area (CSA) and wall thickness of the Ang II-treated Thbs4−/− mice was found. More detailed investigation of the Ang II-treated Thbs4−/− aortas also revealed the appearance of aortic dissections in the outer medial layer of the arteries, as well as pronounced inflammation. No differences were found in several other extracellular matrix-related parameters, such as number of elastin breaks or stress–strain relationships. However, at the ultrastructural level, collagen fibers showed alterations in diameter in the media and adventitia of the Ang II-treated Thbs4−/− mice, in the area prone to dissection. In conclusion, we identified TSP-4 as an important protein in the development of cardiac hypertrophy and aortic dissections in Ang II-induced hypertension.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- aortic dissection
- heart hypertrophy
- perivascular fibrosis
- thrombospondin 4
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Palao, Teresa
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Medzikovic, Lejl ...
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Rippe, Catarina
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Wanga, Shaynah
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Al-Mardini, Clau ...
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van Weert, Angel ...
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show more...
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de Vos, Judith
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van der Wel, Nic ...
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van Veen, Henk A ...
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van Bavel, Ed T.
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Swärd, Karl
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de Waard, Vivian
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Bakker, Erik NTP
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Cardiovascular P ...
- By the university
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Lund University