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Prognostic implicat...
Prognostic implications of mutation-specific QTc standard deviation in congenital long QT syndrome
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Mathias, Andrew (author)
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Moss, Arthur J. (author)
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Lopes, Coeli M. (author)
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Barsheshet, Alon (author)
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McNitt, Scott (author)
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Zareba, Wojciech (author)
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Robinson, Jennifer L. (author)
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Locati, Emanuela H. (author)
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Ackerman, Michael J. (author)
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Benhorin, Jesaia (author)
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Kaufman, Elizabeth S. (author)
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- Platonov, Pyotr (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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Qi, Ming (author)
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Shimizu, Wataru (author)
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Towbin, Jeffrey A. (author)
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Vincent, G. Michael (author)
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Wilde, ArthurA. M. (author)
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Zhang, Li (author)
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Goldenberg, Ilan (author)
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(creator_code:org_t)
- Elsevier BV, 2013
- 2013
- English.
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In: Heart Rhythm. - : Elsevier BV. - 1547-5271. ; 10:5, s. 720-725
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND Individual corrected QT interval (QTc) may vary widely among carriers of the same long QT syndrome (LOTS) mutation. Currently, neither the mechanism nor the implications of this variable penetrance are well understood. OBJECTIVES To hypothesize that the assessment of QTc variance in patients with congenital LOTS who carry the same mutation provides incremental prognostic information on the patient-specific QTc. METHODS The study population comprised 1206 patients with LOTS with 95 different mutations and >= 5 individuals who carry the same mutation. Multivariate Cox proportional hazards regression analysis was used to assess the effect of mutation-specific standard deviation of QTc (QTcSD) on the risk of cardiac events (comprising syncope, aborted cardiac arrest, and sudden cardiac death) from birth through age 40 years in the total population and by genotype. RESULTS Assessment of mutation-specific QTcSD showed large differences among carriers of the same mutations (median QTcSD 45 ms). Multivariate analysis showed that each 20 ms increment in QTcSD was associated with a significant 33% (P=.002) increase in the risk of cardiac events after adjustment for the patient-specific QTc duration and the family effect on QTc. The risk associated with QTcSD was pronounced among patients with long QT syndrome type 1 (hazard ratio 1.55 per 20 ms increment; P<.001), whereas among patients with long QT syndrome type 2, the risk associated with QTcSD was not statistically significant (hazard ratio 0.99; P=.95; P value for QTcSD-by-genotype interaction=.002). CONCLUSIONS Our findings suggest that mutations with a wider variation in QTc duration are associated with increased risk of cardiac events. These findings appear to be genotype-specific, with a pronounced effect among patients with the long QT syndrome type 1 genotype.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Long QT syndrome
- Corrected QT interval
- Sudden cardiac death
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Mathias, Andrew
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Moss, Arthur J.
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Lopes, Coeli M.
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Barsheshet, Alon
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McNitt, Scott
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Zareba, Wojciech
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show more...
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Robinson, Jennif ...
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Locati, Emanuela ...
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Ackerman, Michae ...
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Benhorin, Jesaia
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Kaufman, Elizabe ...
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Platonov, Pyotr
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Qi, Ming
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Shimizu, Wataru
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Towbin, Jeffrey ...
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Vincent, G. Mich ...
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Wilde, ArthurA. ...
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Zhang, Li
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Goldenberg, Ilan
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Heart Rhythm
- By the university
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Lund University