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Effects of growth a...
Effects of growth and aging on the reference values of pulmonary nitric oxide dynamics in healthy subjects
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- Högman, Marieann (author)
- Uppsala universitet,Uppsala University,Lung- allergi- och sömnforskning
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- Thornadtsson, Alexandra, 1988- (author)
- Uppsala universitet,Uppsala University,Lung- allergi- och sömnforskning,Centrum för klinisk forskning, Gävleborg,Paris Descartes Univ, Dept Resp Physiol, Med Sch, Paris, France.
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- Liv, Per (author)
- Uppsala universitet,Uppsala University,Centrum för klinisk forskning, Gävleborg
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- Hua-Huy, T. (author)
- Paris Descartes University,Paris Descartes Univ, Dept Resp Physiol, Med Sch, Paris, France.
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- Dinh-Xuan, A. T. (author)
- Paris Descartes University
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- Tufvesson, E. (author)
- Lund University,Lunds universitet,Forskargruppen för lungmedicin och allergologi,Forskargrupper vid Lunds universitet,Lungfysiologi och biomarkörer,Respiratory Medicine and Allergology Research Group,Lund University Research Groups,Lung physiology and biomarkers,Lund Univ, Dept Clin Sci Lund Resp Med & Allergol, Lund, Sweden.
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- Dressel, H. (author)
- University of Zurich,Univ Zurich, Epidemiol Biostat & Prevent Inst, Div Occupat & Environm Med, Zurich, Switzerland.
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- Janson, Christer (author)
- Uppsala universitet,Uppsala University,Lung- allergi- och sömnforskning
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- Koskela, K. (author)
- Finnish Institute of Occupational Health,Finnish Inst Occupat Hlth, Tampere, Finland.
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- Oksa, P. (author)
- Finnish Institute of Occupational Health,Finnish Inst Occupat Hlth, Tampere, Finland.
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- Sauni, R. (author)
- Finnish Institute of Occupational Health,Finnish Inst Occupat Hlth, Tampere, Finland.
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- Uitti, J. (author)
- Finnish Institute of Occupational Health,Finnish Inst Occupat Hlth, Tampere, Finland.
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- Moilanen, E. (author)
- University of Tampere,Univ Tampere, Sch Med, Fac Med & Biosci, Immunopharmacol Res Grp, Tampere, Finland.;Tampere Univ Hosp, Tampere, Finland.
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- Lehtimäki, L. (author)
- Tampere University Hospital,Tampere Univ Hosp, Allergy Ctr, Tampere, Finland.;Univ Tampere, Fac Med & Biosci, Tampere, Finland.
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(creator_code:org_t)
- 2017-09-13
- 2017
- English.
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In: Journal of Breath Research. - : IOP Publishing. - 1752-7155 .- 1752-7163. ; 11:4
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Abstract
Subject headings
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- The lung just like all other organs is affected by age. The lung matures by the age of 20 and age-related changes start around middle age, at 40-50 years. Exhaled nitric oxide (FENO) has been shown to be age, height and gender dependent. We hypothesize that the nitric oxide (NO) parameters alveolar NO (CANO), airway flux (JawNO), airway diffusing capacity (DawNO) and airway wall content (CawNO) will also demonstrate this dependence. Data from healthy subjects were gathered by the current authors from their earlier publications in which healthy individuals were included as control subjects. Healthy subjects (n = 433) ranged in age from 7 to 78 years. Age-stratified reference values of the NO parameters were significantly different. Gender differences were only observed in the 20-49 age group. The results from the multiple regression models in subjects older than 20 years revealed that age, height and gender interaction together explained 6% of variation in FENO at 50 ml s-1 (FENO50), 4% in JawNO, 16% in CawNO, 8% in DawNO and 12% in CANO. In conclusion, in this study we have generated reference values for NO parameters from an extended NO analysis of healthy subjects. This is important in order to be able to use these parameters in clinical practice.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- breath test
- health
- mathematical model
- nitric oxide
- pulmonary gas exchange
- breath test
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Högman, Marieann
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Thornadtsson, Al ...
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Liv, Per
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Hua-Huy, T.
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Dinh-Xuan, A. T.
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Tufvesson, E.
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show more...
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Dressel, H.
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Janson, Christer
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Koskela, K.
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Oksa, P.
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Sauni, R.
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Uitti, J.
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Moilanen, E.
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Lehtimäki, L.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Other Medical an ...
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and Gerontology spec ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
- Articles in the publication
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Journal of Breat ...
- By the university
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Lund University
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Uppsala University