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Low expression of h...
Low expression of hexokinase-2 is associated with false-negative FDG–positron emission tomography in multiple myeloma
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- Rasche, Leo (author)
- University of Arkansas for Medical Sciences
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- Angtuaco, Edgardo (author)
- University of Arkansas for Medical Sciences
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- McDonald, James E. (author)
- University of Arkansas for Medical Sciences
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- Buros, Amy (author)
- University of Arkansas for Medical Sciences
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- Stein, Caleb (author)
- University of Arkansas for Medical Sciences
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- Pawlyn, Charlotte (author)
- Institute of Cancer Research London
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- Thanendrarajan, Sharmilan (author)
- University of Arkansas for Medical Sciences
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- Schinke, Carolina (author)
- University of Arkansas for Medical Sciences
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- Samant, Rohan (author)
- University of Arkansas for Medical Sciences
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- Yaccoby, Shmuel (author)
- University of Arkansas for Medical Sciences
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- Walker, Brian A. (author)
- University of Arkansas for Medical Sciences
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- Epstein, Joshua (author)
- University of Arkansas for Medical Sciences
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- Zangari, Maurizio (author)
- University of Arkansas for Medical Sciences
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- Van Rhee, Frits (author)
- University of Arkansas for Medical Sciences
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- Meissner, Tobias (author)
- Avera Cancer Institute
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- Goldschmidt, Hartmut (author)
- Heidelberg University
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- Hemminki, Kari (author)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups
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- Houlston, Richard (author)
- Institute of Cancer Research London
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- Barlogie, Bart (author)
- University of Arkansas for Medical Sciences
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- Davies, Faith E. (author)
- University of Arkansas for Medical Sciences
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- Morgan, Gareth J. (author)
- University of Arkansas for Medical Sciences
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- Weinhold, Niels (author)
- University of Arkansas for Medical Sciences
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(creator_code:org_t)
- American Society of Hematology, 2017
- 2017
- English 5 s.
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In: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 130:1, s. 30-34
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http://dx.doi.org/10...
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Abstract
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- 18F-Fluorodeoxyglucose (FDG)–positron emission tomography (PET) and diffusion-weighted magnetic resonance imaging with background signal suppression (DWIBS) are 2 powerful functional imaging modalities in the evaluation of malignant plasma cell (PC) disease multiple myeloma (MM). Preliminary observations have suggested that MM patients with extensive disease according to DWIBS may be reported as being disease-free on FDG-PET (“PET false-negative”). The aim of this study was to describe the proportion of PET false-negativity in a representative set of 227 newly diagnosed MM patients with simultaneous assessment of FDG-PET and DWIBS, and to identify tumor-intrinsic features associated with this pattern. We found the incidence of PET false-negativity to be 11%. Neither tumor load–associated parameters, such as degree of bone marrow PC infiltration, nor the PC proliferation rate were associated with this subset. However, the gene coding for hexokinase-2, which catalyzes the first step of glycolysis, was significantly lower expressed in PET false-negative cases (5.3-fold change, P < .001) which provides a mechanistic explanation for this feature. In conclusion, we demonstrate a relevant number of patients with FDG-PET false-negative MM and a strong association between hexokinase-2 expression and this negativity: a finding which may also be relevant for clinical imaging of other hematological cancers.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- art (subject category)
- ref (subject category)
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Blood
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- By the author/editor
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Rasche, Leo
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Angtuaco, Edgard ...
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McDonald, James ...
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Buros, Amy
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Stein, Caleb
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Pawlyn, Charlott ...
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show more...
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Thanendrarajan, ...
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Schinke, Carolin ...
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Samant, Rohan
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Yaccoby, Shmuel
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Walker, Brian A.
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Epstein, Joshua
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Zangari, Maurizi ...
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Van Rhee, Frits
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Meissner, Tobias
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Goldschmidt, Har ...
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Hemminki, Kari
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Houlston, Richar ...
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Barlogie, Bart
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Davies, Faith E.
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Morgan, Gareth J ...
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Weinhold, Niels
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Blood
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Lund University