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  • Bjørge, ToneUniversity of Bergen,Cancer Registry of Norway, Institute of Population-Based Cancer Research (author)

BMI and weight changes and risk of obesity-related cancers : a pooled European cohort study

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2019-09-30
  • Oxford University Press (OUP),2019
  • 14 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:baf844cb-8648-4018-a455-af481f301014
  • https://lup.lub.lu.se/record/baf844cb-8648-4018-a455-af481f301014URI
  • https://doi.org/10.1093/ije/dyz188DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-165815URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-406289URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • BACKGROUND: Obesity is an established risk factor for several cancers. Adult weight gain has been associated with increased cancer risk, but studies on timing and duration of adult weight gain are relatively scarce. We examined the impact of BMI (body mass index) and weight changes over time, as well as the timing and duration of excess weight, on obesity- and non-obesity-related cancers. METHODS: We pooled health data from six European cohorts and included 221 274 individuals with two or more height and weight measurements during 1972-2014. Several BMI and weight measures were constructed. Cancer cases were identified through linkage with national cancer registries. Hazard ratios (HRs) of cancer with 95% confidence intervals (CIs) were derived from time-dependent Cox-regression models. RESULTS: During follow-up, 27 881 cancer cases were diagnosed; 9761 were obesity-related. The HR of all obesity-related cancers increased with increasing BMI at first and last measurement, maximum BMI and longer duration of overweight (men only) and obesity. Participants who were overweight before age 40 years had an HR of obesity-related cancers of 1.16 (95% CI 1.02, 1.32) and 1.15 (95% CI 1.04, 1.27) in men and women, respectively, compared with those who were not overweight. The risk increase was particularly high for endometrial (70%), male renal-cell (58%) and male colon cancer (29%). No positive associations were seen for cancers not regarded as obesity-related. CONCLUSIONS: Adult weight gain was associated with increased risk of several major cancers. The degree, timing and duration of overweight and obesity also seemed to be important. Preventing weight gain may reduce the cancer risk.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Häggström, ChristelUppsala universitet,Umeå universitet,Uppsala University,Umeå University,Enheten för biobanksforskning,Näringsforskning,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.,Endokrinkirurgi(Swepub:uu)chrha650 (author)
  • Ghaderi, SaraUniversity of Bergen (author)
  • Nagel, GabrieleAgency for Preventive and Social Medicine Vorarlberg,University of Ulm (author)
  • Manjer, JonasLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital(Swepub:lu)smi-jma (author)
  • Tretli, SteinarCancer Registry of Norway, Institute of Population-Based Cancer Research (author)
  • Ulmer, HannoMedical University of Innsbruck (author)
  • Harlid, SophiaUmeå universitet,Umeå University,Onkologi(Swepub:umu)soha0105 (author)
  • Rosendahl, Ann H.Lund University,Lunds universitet,Bröstcancer - prevention & intervention,Forskargrupper vid Lunds universitet,Breast cancer prevention & intervention,Lund University Research Groups(Swepub:lu)onk-aro (author)
  • Lang, AloisAgency for Preventive and Social Medicine Vorarlberg (author)
  • Stattin, PärUppsala universitet,Umeå universitet,Uppsala University,Urologi och andrologi,Urologkirurgi(Swepub:uu)parst892 (author)
  • Stocks, TanjaUmeå universitet,Lund University,Lunds universitet,Registerbaserad epidemiologi,Forskargrupper vid Lunds universitet,Register-based epidemiology,Lund University Research Groups,Urologi och andrologi(Swepub:umu)taasts96 (author)
  • Engeland, AndersNorwegian Institute of Public Health,University of Bergen (author)
  • University of BergenCancer Registry of Norway, Institute of Population-Based Cancer Research (creator_code:org_t)

Related titles

  • In:International Journal of Epidemiology: Oxford University Press (OUP)48:6, s. 1872-18851464-36850300-5771

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