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Natural killer cell...
Natural killer cell activity and antibody-dependent cellular cytotoxicity in newborn infants
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- Hallberg, A (author)
- Lund University,Skåne University Hospital
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- Malmström, P (author)
- Lund University,Lunds universitet,Wallenberglaboratoriet, Lund,Medicinska fakulteten,The Wallenberg Laboratory,Faculty of Medicine,Skåne University Hospital
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(creator_code:org_t)
- Wiley, 1982
- 1982
- English.
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In: Acta Paediatrica Scandinavica. - : Wiley. - 0001-656X .- 0803-5253 .- 1651-2227. ; 71:3, s. 431-436
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http://dx.doi.org/10...
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Abstract
Subject headings
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- The ability of lymphocytes from the peripheral blood of preterm and term infants and adult women and men to mediate natural killing (NK) and K cell activity (antibody-dependent cellular cytotoxicity) was analysed in 4 hours 51Cr-release assays. K 562 cells were targets for NK activity. K cell activity was assayed on antibody-coated rat thymocytes. Lymphocytes from adult male donors were significantly more cytotoxic to K 562 cells than were lymphocytes from adult female donors. Lymphocytes from both preterm and term infants had significantly lower NK and K cell activity than lymphocytes from adult donors. During the first month of life no increase in NK activity or K cell activity occurred in 7 infants who were re-examined. It is concluded that neither NK nor K cell activities are fully developed during the first month of life.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Adult
- Antibody-Dependent Cell Cytotoxicity
- Cytotoxicity, Immunologic
- Female
- Humans
- Infant
- Infant, Newborn
- Infant, Premature
- Killer Cells, Natural/immunology
- Lymphocytes/immunology
- Male
Publication and Content Type
- art (subject category)
- ref (subject category)
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