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Poly(propylene imin...
Poly(propylene imine) dendrimers with histidine-maltose shell as novel type of nanoparticles for synapse and memory protection.
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- Aso, Ester (author)
- Bellvitge University Hospital-IDIBELL
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- Martinsson, Isak (author)
- Lund University,Lunds universitet,Experimentell demensforskning,Forskargrupper vid Lunds universitet,Wallenberg Neurocentrum, Lund,Medicinska fakulteten,Experimental Dementia Research,Lund University Research Groups,Wallenberg Neuroscience Centre, Lund,Faculty of Medicine
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- Appelhans, Dietmar (author)
- Leibniz Institute of Polymer Research (IPF)
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- Effenberg, C (author)
- Leibniz Institute of Polymer Research (IPF)
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- Benseny-Cases, Núria (author)
- Autonomous University of Barcelona
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- Gouras, Gunnar (author)
- Lund University,Lunds universitet,Experimentell demensforskning,Forskargrupper vid Lunds universitet,Wallenberg Neurocentrum, Lund,Medicinska fakulteten,Experimental Dementia Research,Lund University Research Groups,Wallenberg Neuroscience Centre, Lund,Faculty of Medicine
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- Ferrer, Isidre (author)
- Bellvitge University Hospital-IDIBELL
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- Klementieva, Oxana (author)
- Lund University,Lunds universitet,Wallenberg Neurocentrum, Lund,Medicinska fakulteten,Medicinsk mikrospektroskopi,Forskargrupper vid Lunds universitet,Wallenberg Neuroscience Centre, Lund,Faculty of Medicine,Medical Microspectroscopy,Lund University Research Groups,Bellvitge University Hospital-IDIBELL
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(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- English.
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In: Nanomedicine: Nanotechnology, Biology, and Medicine. - : Elsevier BV. - 1549-9642 .- 1549-9634. ; , s. 198-209
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Abstract
Subject headings
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- Poly(propylene imine) dendrimers have been shown to be promising 3-dimensional polymers for the use in the pharmaceutical and biomedical applications. Our aims of this study were first, to synthesize a novel type of dendrimer with poly(propylene imine) core and maltose-histidine shell (G4HisMal) assessing if maltose-histidine shell can improve the biocompatibility and the ability to cross the blood brain barrier, and second, to investigate the potential of G4HisMal to protect Alzheimer disease transgenic mice from memory impairment. Our data demonstrate that G4HisMal has significantly improved biocompatibility and ability to cross the blood brain barrier in vivo. Therefore, we suggest that a maltose-histidine shell can be used to improve biocompatibility and ability to cross the blood brain barrier of dendrimers. Moreover, G4HisMal demonstrated properties for synapse and memory protection when administered to Alzheimer disease transgenic mice. Therefore, G4HisMal can be considered as a promising drug candidate to prevent Alzheimer disease via synapse protection.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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