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Cross-sectional stu...
Cross-sectional study on acrylamide hemoglobin adducts in subpopulations from the European Prospective Investigation into Cancer and Nutrition (EPIC) study
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Vesper, Hubert W. (author)
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Slimani, Nadia (author)
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Hallmans, Goran (author)
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Tjonneland, Anne (author)
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Agudo, Antonio (author)
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Benetou, Vassiliki (author)
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Bingham, Sheila (author)
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Boeing, Heiner (author)
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Boutron-Ruault, Marie-Christine (author)
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Bueno-de-Mesquita, H. Bas (author)
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Chirlaque, Dolores (author)
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Clavel-Chapelon, Francoise (author)
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Crowe, Francesca (author)
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Drogan, Dagmar (author)
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Ferrari, Pietro (author)
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Johansson, Ingegerd (author)
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Kaaks, Rudolf (author)
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Linseisen, Jakob (author)
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Lund, Eiliv (author)
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- Manjer, Jonas (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
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Mattiello, Amalia (author)
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Palli, Domenico (author)
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Peeters, Petra H. M. (author)
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Rinaldi, Sabina (author)
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Skeie, Guri (author)
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Trichopoulou, Antonia (author)
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Vineis, Paolo (author)
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- Wirfält, Elisabet (author)
- Lund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups
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Overvad, Kim (author)
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- Strömberg, Ulf (author)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine
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(creator_code:org_t)
- 2008-07-15
- 2008
- English.
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In: Journal of Agricultural and Food Chemistry. - : American Chemical Society (ACS). - 0021-8561 .- 1520-5118. ; 56:15, s. 6046-6053
- Related links:
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http://dx.doi.org/10...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Acrylamide exposure was investigated in subgroups of the EPIC study population (510 subjects from 9 European countries, randomly selected and stratified by age, gender, and smoking status) using hemoglobin adducts of acrylamide (HbAA) and its primary metabolite glycidamide (HbGA). Blood samples were analyzed for HbAA and HbGA by HPLC/MS/MS. Statistical models for HbAA and HbGA were developed including body mass index (BMI), educational level, and physical activity. A large variability in acrylamide exposure and metabolism between individuals and country groups was observed with HbAA and HbGA values ranging between 15-623 and 8-377 pmol/g of Hb, respectively. Both adducts differed significantly by country, sex, and smoking status. HbGA values were significantly lower in high alcohol consumers than in moderate consumers. With increasing BMI, HbGA in nonsmokers and HbAA in smokers decreased significantly. In the assessment of potential health effects related to acrylamide exposure, country of origin, BMI, alcohol consumption, sex, and smoking status should be considered.
Subject headings
- LANTBRUKSVETENSKAPER -- Lantbruksvetenskap, skogsbruk och fiske (hsv//swe)
- AGRICULTURAL SCIENCES -- Agriculture, Forestry and Fisheries (hsv//eng)
Keyword
- smoking
- Cancer
- European Prospective Investigation into
- acrylamide
- glycidamide
- alcohol consumption
- gender
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Vesper, Hubert W ...
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Slimani, Nadia
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Hallmans, Goran
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Tjonneland, Anne
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Agudo, Antonio
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Benetou, Vassili ...
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show more...
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Bingham, Sheila
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Boeing, Heiner
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Boutron-Ruault, ...
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Bueno-de-Mesquit ...
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Chirlaque, Dolor ...
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Clavel-Chapelon, ...
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Crowe, Francesca
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Drogan, Dagmar
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Ferrari, Pietro
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Johansson, Ingeg ...
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Kaaks, Rudolf
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Linseisen, Jakob
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Lund, Eiliv
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Manjer, Jonas
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Mattiello, Amali ...
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Palli, Domenico
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Peeters, Petra H ...
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Rinaldi, Sabina
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Skeie, Guri
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Trichopoulou, An ...
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Vineis, Paolo
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Wirfält, Elisabe ...
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Overvad, Kim
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Strömberg, Ulf
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show less...
- About the subject
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- AGRICULTURAL SCIENCES
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AGRICULTURAL SCI ...
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and Agriculture Fore ...
- Articles in the publication
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Journal of Agric ...
- By the university
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Lund University