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Myelodysplastic Syn...
Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo.
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Woll, Petter S (author)
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- Kjällquist, Una (author)
- Karolinska Institutet
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Chowdhury, Onima (author)
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Doolittle, Helen (author)
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Wedge, David C (author)
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Thongjuea, Supat (author)
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Erlandsson, Rikard (author)
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- Ngara, Mtakai (author)
- Karolinska Institutet
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- Anderson, Kristina (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
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- Deng, Qiaolin (author)
- Karolinska Institutet
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Mead, Adam J (author)
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Stenson, Laura (author)
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Giustacchini, Alice (author)
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Duarte, Sara (author)
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Giannoulatou, Eleni (author)
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Taylor, Stephen (author)
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- Karimi, Mohsen (author)
- Karolinska Institutet
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Scharenberg, Christian (author)
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- Mortera-Blanco, Teresa (author)
- Karolinska Institutet
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Macaulay, Iain C (author)
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Clark, Sally-Ann (author)
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Dybedal, Ingunn (author)
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Josefsen, Dag (author)
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Fenaux, Pierre (author)
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Hokland, Peter (author)
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Holm, Mette S (author)
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Cazzola, Mario (author)
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Malcovati, Luca (author)
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Tauro, Sudhir (author)
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Bowen, David (author)
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Boultwood, Jacqueline (author)
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Pellagatti, Andrea (author)
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Pimanda, John E (author)
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Unnikrishnan, Ashwin (author)
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Vyas, Paresh (author)
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Göhring, Gudrun (author)
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Schlegelberger, Brigitte (author)
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- Tobiasson, Magnus (author)
- Karolinska Institutet
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Kvalheim, Gunnar (author)
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Constantinescu, Stefan N (author)
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- Nerlov, Claus (author)
- Lund University,Lunds universitet,Avdelningen för molekylärmedicin och genterapi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Division of Molecular Medicine and Gene Therapy,Department of Laboratory Medicine,Faculty of Medicine,Stem Cell Center,Division of stem cell research
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- Nilsson, Lars (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
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Campbell, Peter J (author)
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- Sandberg, Rickard (author)
- Karolinska Institutet
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Papaemmanuil, Elli (author)
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- Hellström-Lindberg, Eva (author)
- Karolinska Institutet
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- Linnarsson, Sten (author)
- Karolinska Institutet
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- Jacobsen, Sten Eirik W (author)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2014
- 2014
- English.
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In: Cancer Cell. - : Elsevier BV. - 1878-3686 .- 1535-6108. ; 25:6, s. 794-808
- Related links:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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http://www.cell.com/...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
Close
- Evidence for distinct human cancer stem cells (CSCs) remains contentious and the degree to which different cancer cells contribute to propagating malignancies in patients remains unexplored. In low- to intermediate-risk myelodysplastic syndromes (MDS), we establish the existence of rare multipotent MDS stem cells (MDS-SCs), and their hierarchical relationship to lineage-restricted MDS progenitors. All identified somatically acquired genetic lesions were backtracked to distinct MDS-SCs, establishing their distinct MDS-propagating function in vivo. In isolated del(5q)-MDS, acquisition of del(5q) preceded diverse recurrent driver mutations. Sequential analysis in del(5q)-MDS revealed genetic evolution in MDS-SCs and MDS-progenitors prior to leukemic transformation. These findings provide definitive evidence for rare human MDS-SCs in vivo, with extensive implications for the targeting of the cells required and sufficient for MDS-propagation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
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Woll, Petter S
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Kjällquist, Una
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Chowdhury, Onima
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Doolittle, Helen
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Wedge, David C
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Thongjuea, Supat
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show more...
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Erlandsson, Rika ...
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Ngara, Mtakai
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Anderson, Kristi ...
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Deng, Qiaolin
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Mead, Adam J
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Stenson, Laura
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Giustacchini, Al ...
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Duarte, Sara
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Giannoulatou, El ...
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Taylor, Stephen
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Karimi, Mohsen
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Scharenberg, Chr ...
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Mortera-Blanco, ...
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Macaulay, Iain C
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Clark, Sally-Ann
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Dybedal, Ingunn
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Josefsen, Dag
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Fenaux, Pierre
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Hokland, Peter
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Holm, Mette S
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Cazzola, Mario
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Malcovati, Luca
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Tauro, Sudhir
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Bowen, David
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Boultwood, Jacqu ...
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Pellagatti, Andr ...
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Pimanda, John E
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Unnikrishnan, As ...
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Vyas, Paresh
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Göhring, Gudrun
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Schlegelberger, ...
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Tobiasson, Magnu ...
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Kvalheim, Gunnar
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Constantinescu, ...
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Nerlov, Claus
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Nilsson, Lars
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Campbell, Peter ...
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Sandberg, Rickar ...
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Papaemmanuil, El ...
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Hellström-Lindbe ...
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Linnarsson, Sten
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Jacobsen, Sten E ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancer Cell
- By the university
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Lund University
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Karolinska Institutet