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Physiological properties of the peritoneum in an adult peritoneal dialysis population over a three-year period
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- Johansson, Ann-Cathrine (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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- Haraldsson, Börje, 1957 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine
- (creator_code:org_t)
- 2006
- 2006
- English.
- In: Peritoneal Dialysis International. - 1718-4304. ; 26:4, s. 482-9
- Journal article (peer-reviewed)
Abstract
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- Objectives: To describe the physiological properties of the peritoneal membrane in adult patients treated with peritoneal dialysis (PD) and to analyze the effects of patient characteristics and time. Design: Observational study. Setting: Department of Nephrology at the Sahlgrenska University Hospital. Method: Peritoneal function was analyzed by the Personal Dialysis Capacity (PDC) test, based on the three-pore theory of capillary transport. The functional PDC variables are absorption, large-pore flow, and the area parameter (A(0)/Delta x), which determines the diffusion of small solutes. The ultrafiltration (UF) coefficient is determined mainly by A(0)/Delta x. Patients: All patients (n = 280) who had at least one PDC test done between September 1990 and August 1999. Results: In 249 patients examined soon after start of PD, area was 19000 (SD 7100) cm(2)/cm/1.73 m(2), large-pore flow 0.112 (SD 0.052) mL/min/1.73 m(2), and the UF coefficient 0.071 (SD 0.032) mL/minute/mmHg/1.73 m(2). Absorption was 1.54 (SD +2.64, -0.97) mL/min/1.73 m(2). Large-pore flow was greater in patients with severe comorbidity than in patients with fewer comorbid conditions. Elderly patients had a lower UF coefficient than did younger patients (p < 0.05). Repeated PDC tests were performed in 208 patients during a mean observation time of 18.4 months. There was a slight increase in the slope of the area-versus-time curve of 54 cm(2)/cm/1.73 m(2) per month (approximately 10% after 3 years, p < 0.01); all other parameters remained constant. Conclusion: Patient characteristics have an impact on peritoneal performance already at the start of dialysis. Peritoneal function can remain essentially stable during medium long-term PD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- peritoneal physiology
- Personal Dialysis Capacity (PDC)
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- art (subject category)
- ref (subject category)
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