onr:"swepub:oai:lup.lub.lu.se:bdcc5b26-4bf2-403e-b2f5-751146d8e866"
Search: onr:"swepub:oai:lup.lub.lu.se:bdcc5b26-4bf2-403e-b2f5-751146d8e866" > Crohn's disease ass...
- 1 of 1
- Previous record
- Next record
- To hitlist
Crohn's disease associated CARD15 (NOD2) variants are not involved in the susceptibility to type 1 diabetes
- Ghandil, P (author)
- Chelala, C (author)
- Dubois-Laforgue, D (author)
- show more...
- Senee, V (author)
- Caillat-Zucman, S (author)
- Nerup, J (author)
- Pociot, F (author)
- Timsit, J (author)
- Julier, C (author)
- show less...
- (creator_code:org_t)
- Elsevier BV, 2005
- 2005
- English.
- In: Molecular Genetics and Metabolism. - : Elsevier BV. - 1096-7192. ; 86:3, s. 379-383
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Three variants in the caspase recruitment domain 15/nucleotide-binding oligomerization domain 2 (CARD15/NOD2) gene have been shown to be associated with Crohn's disease (CD). There is a strong support for shared genetic determinants between various autoimmune and inflammatory diseases. In particular, linkage of type 1 diabetes (T1D) and other autoimmune and inflammatory diseases has been reported on chromosome 16, encompassing the region containing the CARD15 gene. We therefore considered this gene as a good candidate for the T1D locus mapped to this region, and we tested the three CARD15 variants in the susceptibility to T I D in two independent settings: family based association analysis in Scandinavian multiplex families that we previously showed to be linked to this region, and case/control association study in a large cohort of French diabetic patients. We found no evidence for association of these variants with T1D overall, nor in subgroups of patients with or without the major risk genotypes at HLA-DRB1, at insulin (INS), or positive or negative for autoantibodies specific to other autoimmune diseases. Our results do not support a role for CD-associated CARD15 variants in the susceptibility to T1D, and suggest that another gene is responsible for the shared susceptibility between autoimmune and inflammatory diseases mapping to this region.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- Crohn's disease
- genetic variant
- association
- type 1 diabetes
- genetics
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
- Molecular Genetics and Metabolism (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Ghandil, P
- Chelala, C
- Dubois-Laforgue, ...
- Senee, V
- Caillat-Zucman, ...
- Kockum, I
- show more...
- Luthman, Holger
- Nerup, J
- Pociot, F
- Timsit, J
- Julier, C
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Medical Genetics
- Articles in the publication
- Molecular Geneti ...
- By the university
- Lund University
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
