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Effect Modification...
Effect Modification between Genes and Environment and Parkinson's Disease Risk
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- Periñán, Maria Teresa (author)
- University Hospital Virgen del Rocío
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- Brolin, Kajsa (author)
- Lund University,Lunds universitet,Translationell Neurogenetik,Forskargrupper vid Lunds universitet,Translational Neurogenetics,Lund University Research Groups
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- Bandres-Ciga, Sara (author)
- National Institutes of Health, United States
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- Blauwendraat, Cornelis (author)
- National Institutes of Health, United States
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- Klein, Christine (author)
- University of Lübeck
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- Gan-Or, Ziv (author)
- Montreal Neurological Institute & Hospital
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- Singleton, Andrew (author)
- National Institutes of Health, United States
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- Gomez-Garre, Pilar (author)
- University Hospital Virgen del Rocío
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- Swanberg, Maria (author)
- Lund University,Lunds universitet,Translationell Neurogenetik,Forskargrupper vid Lunds universitet,Translational Neurogenetics,Lund University Research Groups
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- Mir, Pablo (author)
- University Hospital Virgen del Rocío
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- Noyce, Alastair (author)
- Queen Mary University
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(creator_code:org_t)
- 2022-09-24
- 2022
- English 10 s.
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In: Annals of Neurology. - : Wiley. - 0364-5134 .- 1531-8249. ; 92:5, s. 715-724
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Abstract
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- Parkinson's disease (PD) is a complex neurodegenerative condition in which genetic and environmental factors interact to contribute to its etiology. Remarkable progress has been made in deciphering disease etiology through genetic approaches, but there is limited data about how environmental and genetic factors interact to modify penetrance, risk, and disease severity. Here, we provide insights into environmental modifiers of PD, discussing precedents from other neurological and non-neurological conditions. Based on these examples, we outline genetic and environmental factors contributing to PD and review potential environmental modifiers of penetrance and clinical variability in monogenic and idiopathic PD. We also highlight the potential challenges and propose how future studies might tackle these important questions. ANN NEUROL 2022.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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- By the author/editor
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Periñán, Maria T ...
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Brolin, Kajsa
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Bandres-Ciga, Sa ...
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Blauwendraat, Co ...
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Klein, Christine
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Gan-Or, Ziv
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show more...
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Singleton, Andre ...
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Gomez-Garre, Pil ...
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Swanberg, Maria
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Mir, Pablo
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Noyce, Alastair
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Annals of Neurol ...
- By the university
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Lund University