SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:lup.lub.lu.se:be322093-45b8-4b8c-9336-2ad3b71f1040"
 

Search: onr:"swepub:oai:lup.lub.lu.se:be322093-45b8-4b8c-9336-2ad3b71f1040" > The impact of demog...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Ossenkoppele, RikLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam (author)

The impact of demographic, clinical, genetic, and imaging variables on tau PET status

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2020-11-19
  • Springer Science and Business Media LLC,2021
  • 14 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:be322093-45b8-4b8c-9336-2ad3b71f1040
  • https://lup.lub.lu.se/record/be322093-45b8-4b8c-9336-2ad3b71f1040URI
  • https://doi.org/10.1007/s00259-020-05099-wDOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Purpose: A substantial proportion of amyloid-β (Aβ)+ patients with clinically diagnosed Alzheimer’s disease (AD) dementia and mild cognitive impairment (MCI) are tau PET–negative, while some clinically diagnosed non-AD neurodegenerative disorder (non-AD) patients or cognitively unimpaired (CU) subjects are tau PET–positive. We investigated which demographic, clinical, genetic, and imaging variables contributed to tau PET status. Methods: We included 2338 participants (430 Aβ+ AD dementia, 381 Aβ+ MCI, 370 non-AD, and 1157 CU) who underwent [18F]flortaucipir (n = 1944) or [18F]RO948 (n = 719) PET. Tau PET positivity was determined in the entorhinal cortex, temporal meta-ROI, and Braak V-VI regions using previously established cutoffs. We performed bivariate binary logistic regression models with tau PET status (positive/negative) as dependent variable and age, sex, APOEε4, Aβ status (only in CU and non-AD analyses), MMSE, global white matter hyperintensities (WMH), and AD-signature cortical thickness as predictors. Additionally, we performed multivariable binary logistic regression models to account for all other predictors in the same model. Results: Tau PET positivity in the temporal meta-ROI was 88.6% for AD dementia, 46.5% for MCI, 9.5% for non-AD, and 6.1% for CU. Among Aβ+ participants with AD dementia and MCI, lower age, MMSE score, and AD-signature cortical thickness showed the strongest associations with tau PET positivity. In non-AD and CU participants, presence of Aβ was the strongest predictor of a positive tau PET scan. Conclusion: We identified several demographic, clinical, and neurobiological factors that are important to explain the variance in tau PET retention observed across the AD pathological continuum, non-AD neurodegenerative disorders, and cognitively unimpaired persons.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Leuzy, AntoineLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)an3415le (author)
  • Cho, HannaYonsei University,Severance Hospital (author)
  • Sudre, Carole H.King's College London,University College London (author)
  • Strandberg, OlofLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)teor-osn (author)
  • Smith, RubenLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)mphy-rsm (author)
  • Palmqvist, SebastianLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)med-spa (author)
  • Mattsson-Carlgren, NiklasLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Brain Injury After Cardiac Arrest,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Clinical Memory Research,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,Skåne University Hospital(Swepub:lu)med-nmn (author)
  • Olsson, TomasSkåne University Hospital (author)
  • Jögi, JonasSkåne University Hospital(Swepub:lu)klin-jjo (author)
  • Stormrud, ErikLund University,Skåne University Hospital (author)
  • Ryu, Young HoonYonsei University,Severance Hospital (author)
  • Choi, Jae YongKorea Institute of Radiological & Medical Sciences (KIRAMS),Severance Hospital,Yonsei University (author)
  • Boxer, Adam L.University of California, San Francisco (author)
  • Gorno-Tempini, Maria L.University of California, San Francisco (author)
  • Miller, Bruce L.University of California, San Francisco (author)
  • Soleimani-Meigooni, DavidUniversity of California, San Francisco (author)
  • Iaccarino, LeonardoUniversity of California, San Francisco (author)
  • La Joie, RenaudUniversity of California, San Francisco (author)
  • Borroni, EdilioF. Hoffmann-La Roche AG (author)
  • Klein, GregoryF. Hoffmann-La Roche AG (author)
  • Pontecorvo, Michael J.Avid Radiopharmaceuticals, Inc (author)
  • Devous, Michael D.Avid Radiopharmaceuticals, Inc (author)
  • Villeneuve, SylviaMcGill University (author)
  • Lyoo, Chul HyoungSeverance Hospital,Yonsei University (author)
  • Rabinovici, Gil D.University of California, San Francisco,Lawrence Berkeley National Laboratory,F. Hoffmann-La Roche AG (author)
  • Hansson, OskarLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)mphy-ohn (author)
  • Klinisk minnesforskningForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:European Journal of Nuclear Medicine and Molecular Imaging: Springer Science and Business Media LLC48:7, s. 2245-22581619-70701619-7089

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view