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The impact of demog...
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Ossenkoppele, RikLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam
(author)
The impact of demographic, clinical, genetic, and imaging variables on tau PET status
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2020-11-19
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Springer Science and Business Media LLC,2021
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14 s.
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:be322093-45b8-4b8c-9336-2ad3b71f1040
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https://lup.lub.lu.se/record/be322093-45b8-4b8c-9336-2ad3b71f1040URI
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https://doi.org/10.1007/s00259-020-05099-wDOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Purpose: A substantial proportion of amyloid-β (Aβ)+ patients with clinically diagnosed Alzheimer’s disease (AD) dementia and mild cognitive impairment (MCI) are tau PET–negative, while some clinically diagnosed non-AD neurodegenerative disorder (non-AD) patients or cognitively unimpaired (CU) subjects are tau PET–positive. We investigated which demographic, clinical, genetic, and imaging variables contributed to tau PET status. Methods: We included 2338 participants (430 Aβ+ AD dementia, 381 Aβ+ MCI, 370 non-AD, and 1157 CU) who underwent [18F]flortaucipir (n = 1944) or [18F]RO948 (n = 719) PET. Tau PET positivity was determined in the entorhinal cortex, temporal meta-ROI, and Braak V-VI regions using previously established cutoffs. We performed bivariate binary logistic regression models with tau PET status (positive/negative) as dependent variable and age, sex, APOEε4, Aβ status (only in CU and non-AD analyses), MMSE, global white matter hyperintensities (WMH), and AD-signature cortical thickness as predictors. Additionally, we performed multivariable binary logistic regression models to account for all other predictors in the same model. Results: Tau PET positivity in the temporal meta-ROI was 88.6% for AD dementia, 46.5% for MCI, 9.5% for non-AD, and 6.1% for CU. Among Aβ+ participants with AD dementia and MCI, lower age, MMSE score, and AD-signature cortical thickness showed the strongest associations with tau PET positivity. In non-AD and CU participants, presence of Aβ was the strongest predictor of a positive tau PET scan. Conclusion: We identified several demographic, clinical, and neurobiological factors that are important to explain the variance in tau PET retention observed across the AD pathological continuum, non-AD neurodegenerative disorders, and cognitively unimpaired persons.
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Leuzy, AntoineLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)an3415le
(author)
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Cho, HannaYonsei University,Severance Hospital
(author)
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Sudre, Carole H.King's College London,University College London
(author)
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Strandberg, OlofLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)teor-osn
(author)
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Smith, RubenLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)mphy-rsm
(author)
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Palmqvist, SebastianLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)med-spa
(author)
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Mattsson-Carlgren, NiklasLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Brain Injury After Cardiac Arrest,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Clinical Memory Research,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,Skåne University Hospital(Swepub:lu)med-nmn
(author)
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Olsson, TomasSkåne University Hospital
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Jögi, JonasSkåne University Hospital(Swepub:lu)klin-jjo
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Stormrud, ErikLund University,Skåne University Hospital
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Ryu, Young HoonYonsei University,Severance Hospital
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Choi, Jae YongKorea Institute of Radiological & Medical Sciences (KIRAMS),Severance Hospital,Yonsei University
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Boxer, Adam L.University of California, San Francisco
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Gorno-Tempini, Maria L.University of California, San Francisco
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Miller, Bruce L.University of California, San Francisco
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Soleimani-Meigooni, DavidUniversity of California, San Francisco
(author)
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Iaccarino, LeonardoUniversity of California, San Francisco
(author)
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La Joie, RenaudUniversity of California, San Francisco
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Borroni, EdilioF. Hoffmann-La Roche AG
(author)
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Klein, GregoryF. Hoffmann-La Roche AG
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Pontecorvo, Michael J.Avid Radiopharmaceuticals, Inc
(author)
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Devous, Michael D.Avid Radiopharmaceuticals, Inc
(author)
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Villeneuve, SylviaMcGill University
(author)
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Lyoo, Chul HyoungSeverance Hospital,Yonsei University
(author)
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Rabinovici, Gil D.University of California, San Francisco,Lawrence Berkeley National Laboratory,F. Hoffmann-La Roche AG
(author)
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Hansson, OskarLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)mphy-ohn
(author)
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Klinisk minnesforskningForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:European Journal of Nuclear Medicine and Molecular Imaging: Springer Science and Business Media LLC48:7, s. 2245-22581619-70701619-7089
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Ossenkoppele, Ri ...
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Leuzy, Antoine
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Cho, Hanna
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Sudre, Carole H.
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Strandberg, Olof
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Smith, Ruben
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Palmqvist, Sebas ...
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Mattsson-Carlgre ...
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Olsson, Tomas
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Jögi, Jonas
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Stormrud, Erik
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Ryu, Young Hoon
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Choi, Jae Yong
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Boxer, Adam L.
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Gorno-Tempini, M ...
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Miller, Bruce L.
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Soleimani-Meigoo ...
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Iaccarino, Leona ...
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La Joie, Renaud
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Borroni, Edilio
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Klein, Gregory
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Pontecorvo, Mich ...
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Devous, Michael ...
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Villeneuve, Sylv ...
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Lyoo, Chul Hyoun ...
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Rabinovici, Gil ...
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Hansson, Oskar
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