Search: onr:"swepub:oai:lup.lub.lu.se:be4d297c-ccbb-467a-a79d-d7de56b692d2" >
Grain and dietary f...
Grain and dietary fiber intake and bladder cancer risk : a pooled analysis of prospective cohort studies
-
- Yu, Evan Y.W. (author)
- Maastricht University
-
- Wesselius, Anke (author)
- Maastricht University
-
- Mehrkanoon, Siamak (author)
- Maastricht University
-
show more...
-
- Brinkman, Maree (author)
- Maastricht University,Cancer Council Victoria
-
- van den Brandt, Piet (author)
- Maastricht University
-
- White, Emily (author)
- Fred Hutchinson Cancer Research Center
-
- Weiderpass, Elisabete (author)
- International Agency for Research on Cancer, World Health Organization
-
- Le Calvez-Kelm, Florence (author)
- International Agency for Research on Cancer, World Health Organization
-
- Gunter, Marc (author)
- International Agency for Research on Cancer, World Health Organization
-
- Huybrechts, Inge (author)
- International Agency for Research on Cancer, World Health Organization
-
- Liedberg, Fredrik (author)
- Lund University,Lunds universitet,Urologi - blåscancer, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Urinblåsecancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Urology - urothelial cancer, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Urothelial cancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
-
- Skeie, Guri (author)
- UiT The Arctic University of Norway, Tromsø
-
- Tjonneland, Anne (author)
- Danish Cancer Society,University of Copenhagen
-
- Riboli, Elio (author)
- Imperial College London
-
- Giles, Graham G. (author)
- Cancer Council Victoria,Monash University
-
- Milne, Roger L. (author)
- Cancer Council Victoria,Monash University
-
- Zeegers, Maurice P. (author)
- Maastricht University,University of Birmingham
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- English 15 s.
-
In: The American journal of clinical nutrition. - : Elsevier BV. - 1938-3207 .- 0002-9165. ; 112:5, s. 1252-1266
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://academic.oup...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- BACKGROUND: Higher intakes of whole grains and dietary fiber have been associated with lower risk of insulin resistance, hyperinsulinemia, and inflammation, which are known predisposing factors for cancer. OBJECTIVES: Because the evidence of association with bladder cancer (BC) is limited, we aimed to assess associations with BC risk for intakes of whole grains, refined grains, and dietary fiber. METHODS: We pooled individual data from 574,726 participants in 13 cohort studies, 3214 of whom developed incident BC. HRs, with corresponding 95% CIs, were estimated using Cox regression models stratified on cohort. Dose-response relations were examined using fractional polynomial regression models. RESULTS: We found that higher intake of total whole grain was associated with lower risk of BC (comparing highest with lowest intake tertile: HR: 0.87; 95% CI: 0.77, 0.98; HR per 1-SD increment: 0.95; 95% CI: 0.91, 0.99; P for trend: 0.023). No association was observed for intake of total refined grain. Intake of total dietary fiber was also inversely associated with BC risk (comparing highest with lowest intake tertile: HR: 0.86; 95% CI: 0.76, 0.98; HR per 1-SD increment: 0.91; 95% CI: 0.82, 0.98; P for trend: 0.021). In addition, dose-response analyses gave estimated HRs of 0.97 (95% CI: 0.95, 0.99) for intake of total whole grain and 0.96 (95% CI: 0.94, 0.98) for intake of total dietary fiber per 5-g daily increment. When considered jointly, highest intake of whole grains with the highest intake of dietary fiber showed 28% reduced risk (95% CI: 0.54, 0.93; P for trend: 0.031) of BC compared with the lowest intakes, suggesting potential synergism. CONCLUSIONS: Higher intakes of total whole grain and total dietary fiber are associated with reduced risk of BC individually and jointly. Further studies are needed to clarify the underlying mechanisms for these findings.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- bladder cancer
- cohort study
- dietary fiber
- dose-response analysis
- grain
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Yu, Evan Y.W.
-
Wesselius, Anke
-
Mehrkanoon, Siam ...
-
Brinkman, Maree
-
van den Brandt, ...
-
White, Emily
-
show more...
-
Weiderpass, Elis ...
-
Le Calvez-Kelm, ...
-
Gunter, Marc
-
Huybrechts, Inge
-
Liedberg, Fredri ...
-
Skeie, Guri
-
Tjonneland, Anne
-
Riboli, Elio
-
Giles, Graham G.
-
Milne, Roger L.
-
Zeegers, Maurice ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Health Sciences
-
and Nutrition and Di ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
The American jou ...
- By the university
-
Lund University