Search: onr:"swepub:oai:lup.lub.lu.se:be609918-8ce9-4a77-8674-5a5ec7564065" >
Haploidentical Stem...
Haploidentical Stem Cell Transplantation for Refractory/Relapsed Neuroblastoma
-
- Illhardt, Toni (author)
- University Hospital of Tubingen
-
- Toporski, Jacek (author)
- Skåne University Hospital
-
- Feuchtinger, Tobias (author)
- German Center for Lung Research (DZL)
-
show more...
-
- Turkiewicz, Dominik (author)
- Skåne University Hospital
-
- Teltschik, Heiko Manuel (author)
- University Hospital of Tubingen
-
- Ebinger, Martin (author)
- University Hospital of Tubingen
-
- Schwarze, Carl Philipp (author)
- University Hospital of Tubingen
-
- Holzer, Ursula (author)
- University Hospital of Tubingen
-
- Lode, Holger N. (author)
- University Hospital Greifswald
-
- Albert, Michael H. (author)
- German Center for Lung Research (DZL)
-
- Gruhn, Bernd (author)
- Universitätsklinikum Jena
-
- Urban, Christian (author)
- Medical University of Graz
-
- Dykes, Josefina H. (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Region Skåne
-
- Teuffel, Oliver (author)
- University of Tübingen
-
- Schumm, Michael (author)
- University Hospital of Tubingen
-
- Handgretinger, Rupert (author)
- University Hospital of Tubingen
-
- Lang, Peter (author)
- University Hospital of Tubingen
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- English.
-
In: Biology of Blood and Marrow Transplantation. - : Elsevier BV. - 1083-8791. ; 24:5, s. 1005-1012
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
http://www.bbmt.org/...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Pediatric patients with refractory or relapsed metastatic neuroblastoma (NBL) have a poor prognosis despite autologous stem cell transplantation (SCT). Allogeneic SCT from a haploidentical donor has a remarkable alloreactive effect in patients with leukemia; thus, we evaluated this approach in children with very high-risk NBL. We analyzed data from 2 prospective phase I/II trials. A total of 26 patients with refractory (n = 5), metastatic relapsed (n = 20), or locally relapsed MYCN-positive (n = 1) NBL received a median of 17 × 106/kg T/B cell-depleted CD34+ stem cells with 68 × 103/kg residual T cells and 107 × 106/kg natural killer cells. The conditioning regimen comprised melphalan, fludarabine, thiotepa, OKT3, and a short course of mycophenolate mofetil post-transplantation. Engraftment occurred in 96% of the patients. Event-free survival and overall survival at 5 years were 19% and 23%, respectively. No transplantation-related mortality was observed, and the single death was due to progression/subsequent relapse. The median duration of follow-up was 8.1 years. Patients in complete remission before SCT had a significantly better prognosis than those with residual tumor load (P < .01). All patients with progressive disease before SCT relapsed within 1 year. Grade II and grade III acute graft-versus-host disease (GVHD) occurred in 31% and 12% of the patients, respectively. Chronic limited and extensive GVHD occurred in 28% and 10%, respectively. Our data indicate that haploidentical SCT is a feasible treatment option that can induce long-term remission in some patients with NBL with tolerable side effects, and may enable the development of further post-transplantation therapeutic strategies based on the donor-derived immune system.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- Allogeneic stem cell transplantation
- Graft-versus-host disease
- Graft-versus-tumor effect
- Haploidentical
- Neuroblastoma
- Transplantation-related mortality
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Illhardt, Toni
-
Toporski, Jacek
-
Feuchtinger, Tob ...
-
Turkiewicz, Domi ...
-
Teltschik, Heiko ...
-
Ebinger, Martin
-
show more...
-
Schwarze, Carl P ...
-
Holzer, Ursula
-
Lode, Holger N.
-
Albert, Michael ...
-
Gruhn, Bernd
-
Urban, Christian
-
Dykes, Josefina ...
-
Teuffel, Oliver
-
Schumm, Michael
-
Handgretinger, R ...
-
Lang, Peter
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Hematology
- Articles in the publication
-
Biology of Blood ...
- By the university
-
Lund University