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Genetic and environ...
Genetic and environmental interactions modify the risk of diabetes-related autoimmunity by 6 years of age : The teddy study
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- Krischer, Jeffrey P. (author)
- University of South Florida
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- Lynch, Kristian F (author)
- University of South Florida
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- Lernmark, Ake (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Hagopian, William A (author)
- Pacific Northwest Research Institute
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- Rewers, Marian J. (author)
- University of Colorado
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- She, Jin-Xiong (author)
- Medical College of Georgia
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- Toppari, Jorma (author)
- University of Turku,Turku University Hospital
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- Ziegler, Anette G. (author)
- Klinikum rechts der Isar,Helmholtz Zentrum München
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- Akolkar, Beena (author)
- National Institute of Diabetes and Digestive and Kidney Diseases
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(creator_code:org_t)
- 2017-06-23
- 2017
- English 9 s.
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In: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 40:9, s. 1194-1202
- Related links:
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http://dx.doi.org/10...
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https://care.diabete...
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https://lup.lub.lu.s...
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https://doi.org/10.2...
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Abstract
Subject headings
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- OBJECTIVE We tested the associations between genetic background and selected environmental exposures with respect to islet autoantibodies and type 1 diabetes. RESEARCH DESIGN AND METHODS Infants with HLA-DR high-risk genotypes were prospectively followed for diabetesrelated autoantibodies. Single nucleotide polymorphisms (SNPs) came from the Illumina ImmunoChip and environmental exposure data were by parental report. Children were followed to age 6 years. RESULTS Insulin autoantibodies occurred earlier than GAD antibody (GADA) and then declined, while GADA incidence rose and remained constant (significant in HLA-DR4 but not in the DR3/3 children). The presence of SNPs rs2476601 (PTPN22) and rs2292239 (ERBB3) demonstrated increased risk of both autoantibodies to insulin (IAA) only and GADA only. SNP rs689 (INS) was protective of IAA only, but not of GADA only. The rs3757247 (BACH2) SNP demonstrated increased risk of GADA only. Male sex, father or sibling as the diabetic proband, introduction of probiotics under 28 days of age, and weight at age 12 monthswere associated with IAA only, but only father as the diabetic proband and weight at age 12 months were associated with GADA only. Mother as the diabetic proband was not a significant risk factor. CONCLUSIONS These results show clear differences in the initiation of autoimmunity according to genetic factors and environmental exposures that give rise to IAAorGADA as the first appearing indication of autoimmunity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Diabetes
- TEDDY study
- genetic interactions
- enviromental interactions
Publication and Content Type
- art (subject category)
- ref (subject category)
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