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Cerebrospinal fluid...
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Henjum, KristiOslo university hospital
(author)
Cerebrospinal fluid soluble TREM2 in aging and Alzheimer's disease
- Article/chapterEnglish2016
Publisher, publication year, extent ...
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2016-04-27
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Springer Science and Business Media LLC,2016
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:bf6411c3-1b75-4d4e-a0b6-718e0787b3a4
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https://lup.lub.lu.se/record/bf6411c3-1b75-4d4e-a0b6-718e0787b3a4URI
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https://doi.org/10.1186/s13195-016-0182-1DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Background: Alzheimer's disease (AD) neuropathology is associated with neuroinflammation, but there are few useful biomarkers. Mutant variants of triggering receptor expressed on myeloid cells 2 (TREM2) have recently been linked to late-onset AD and other neurodegenerative disorders. TREM2, a microglial receptor, is involved in innate immunity. A cleaved fragment, soluble TREM2 (sTREM2), is present in the cerebrospinal fluid (CSF). Methods: We developed and used a novel enzyme-linked immunosorbent assay to investigate the potential value of CSF sTREM2 as an AD biomarker in two independent cohorts: an AD/mild cognitive impairment (MCI)/control cohort (n = 100) and an AD/control cohort (n = 50). Results: We found no significant difference in sTREM2 levels between groups of controls and patients with AD or MCI. However, among all controls there was a positive correlation between sTREM2 and age (Spearman rho = 0.50; p <0.001; n = 75). In the AD/MCI/control cohort, CSF sTREM2 correlated positively with total Tau (T-tau) (Spearman rho 0.57; p <0.001; n = 50), phosphorylated Tau (P-tau) (Spearman rho 0.63; p <0.001; n = 50) and amyloid-β1-42 (Aβ42) (Spearman rho 0.35; p = 0.01; n = 50) in control subjects. Among controls with a CSF Aβ42 above a cut-off value (700 pg/ml) in this cohort, the positive correlation between sTREM2 and Aβ42 was stronger (Spearman rho = 0.44; p = 0.002; n = 46). Conclusions: sTREM2 in CSF correlates with aging in controls, and with the neurodegenerative markers CSF T-tau/P-tau among controls who are negative for AD CSF core biomarkers Aβ42, T-tau or P-tau.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Almdahl, Ina S.Akershus University Hospital
(author)
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Årskog, VibekeOslo university hospital
(author)
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Minthon, LennartLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)psyk-lmi
(author)
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Hansson, OskarLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)mphy-ohn
(author)
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Fladby, TormodAkershus University Hospital
(author)
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Nilsson, Lars N GOslo university hospital
(author)
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Oslo university hospitalAkershus University Hospital
(creator_code:org_t)
Related titles
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In:Alzheimer's Research & Therapy: Springer Science and Business Media LLC8:11758-9193
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