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Translational oppor...
Translational opportunities of single-cell biology in atherosclerosis
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- De Winther, Menno P.J. (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- Bäck, Magnus (author)
- Karolinska Institutet
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- Evans, Paul (author)
- University of Sheffield
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- Gomez, Delphine (author)
- University of Pittsburgh
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- Goncalves, Isabel (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - translationella studier,Forskargrupper vid Lunds universitet,Cardiovascular Research - Translational Studies,Lund University Research Groups,Skåne University Hospital
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- Jørgensen, Helle F. (author)
- University of Cambridge
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- Koenen, Rory R. (author)
- Maastricht University
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- Lutgens, Esther (author)
- Mayo Clinic Minnesota,Ludwig-Maximilian University of Munich,German Centre for Cardiovascular Research
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- Norata, Giuseppe Danilo (author)
- Bassini Hospital,University of Milan
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- Osto, Elena (author)
- University of Zurich,University Hospital of Zurich
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- Dib, Lea (author)
- Kennedy Institute of Rheumatology
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- Simons, Michael (author)
- Yale University
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- Stellos, Konstantinos (author)
- Heidelberg University
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- Ylä-Herttuala, Seppo (author)
- Kuopio University Hospital
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- Winkels, Holger (author)
- University Hospital of Cologne
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- Bochaton-Piallat, Marie Luce (author)
- University of Geneva
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- Monaco, Claudia (author)
- Kennedy Institute of Rheumatology
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(creator_code:org_t)
- 2022-12-07
- 2023
- English 15 s.
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In: European Heart Journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 44:14, s. 1216-1230
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Abstract
Subject headings
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- The advent of single-cell biology opens a new chapter for understanding human biological processes and for diagnosing, monitoring, and treating disease. This revolution now reaches the field of cardiovascular disease (CVD). New technologies to interrogate CVD samples at single-cell resolution are allowing the identification of novel cell communities that are important in shaping disease development and direct towards new therapeutic strategies. These approaches have begun to revolutionize atherosclerosis pathology and redraw our understanding of disease development. This review discusses the state-of-the-art of single-cell analysis of atherosclerotic plaques, with a particular focus on human lesions, and presents the current resolution of cellular subpopulations and their heterogeneity and plasticity in relation to clinically relevant features. Opportunities and pitfalls of current technologies as well as the clinical impact of single-cell technologies in CVD patient care are highlighted, advocating for multidisciplinary and international collaborative efforts to join the cellular dots of CVD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomedicinsk laboratorievetenskap/teknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomedical Laboratory Science/Technology (hsv//eng)
Keyword
- Atherosclerosis
- Endothelial cell
- Lymphocyte
- Macrophage
- Single-cell biology
- Smooth muscle cell
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- By the author/editor
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De Winther, Menn ...
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Bäck, Magnus
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Evans, Paul
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Gomez, Delphine
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Goncalves, Isabe ...
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Jørgensen, Helle ...
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show more...
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Koenen, Rory R.
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Lutgens, Esther
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Norata, Giuseppe ...
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Osto, Elena
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Dib, Lea
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Simons, Michael
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Stellos, Konstan ...
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Ylä-Herttuala, S ...
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Winkels, Holger
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Bochaton-Piallat ...
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Monaco, Claudia
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Biomedical Labor ...
- Articles in the publication
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European Heart J ...
- By the university
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Lund University
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Karolinska Institutet