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Is Smoking an Indep...
Is Smoking an Independent Risk Factor for Invasive Cervical Cancer? A Nested Case-Control Study Within Nordic Biobanks
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Kapeu, Aline Simen (author)
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Luostarinen, Tapio (author)
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Jellum, Egil (author)
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- Dillner, Joakim (author)
- Karolinska Institutet,Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups
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Hakama, Matti (author)
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Koskela, Pentti (author)
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- Lenner, Per (author)
- Umeå universitet,Onkologi
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Love, Arthur (author)
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Mahlamaki, Eija (author)
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Thoresen, Steinar (author)
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Tryggvadottir, Laufey (author)
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- Wadell, Göran (author)
- Umeå universitet,Virologi
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Youngman, Linda (author)
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Lehtinen, Matti (author)
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(creator_code:org_t)
- 2008-12-13
- 2009
- English.
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In: American Journal of Epidemiology. - Baltimore, Md. : Oxford University Press (OUP). - 0002-9262 .- 1476-6256. ; 169:4, s. 480-488
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Abstract
Subject headings
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- The strong correlation between smoking and exposure to oncogenic human papillomaviruses (HPVs) has made it difficult to verify the independent role of smoking in cervical carcinogenesis. Thus, the authors evaluated this role. Five large Nordic serum banks containing samples from more than 1,000,000 subjects were linked with nationwide cancer registries (1973-2003). Serum samples were retrieved from 588 women who developed invasive cervical cancer and 2,861 matched controls. The samples were analyzed for cotinine (a biomarker of tobacco exposure) and antibodies to HPV types 16 and 18, herpes simplex virus type 2, and Chlamydia trachomatis. Smoking was associated with the risk of squamous cell carcinoma (SCC) among HPV16- and/or HPV18-seropositive heavy smokers (odds ratio = 2.7, 95% confidence interval: 1.7, 4.3). A similar risk of SCC (odds ratio = 3.2, 95% confidence interval: 2.6, 4.0) was found in heavy smokers after adjustment for HPV16/18 antibodies. The point estimates increased with increasing age at diagnosis and increasing cotinine level. This study confirms that smoking is an independent risk factor for cervical cancer/SCC in women infected with oncogenic HPVs. These findings emphasize the importance of cervical cancer prevention among women exposed to tobacco smoke.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- neoplasms
- uterine cervical
- smoking
- risk factors
- carcinoma
- squamous cell
- Carcinoma
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Kapeu, Aline Sim ...
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Luostarinen, Tap ...
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Jellum, Egil
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Dillner, Joakim
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Hakama, Matti
-
Koskela, Pentti
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show more...
-
Lenner, Per
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Love, Arthur
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Mahlamaki, Eija
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Thoresen, Steina ...
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Tryggvadottir, L ...
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Wadell, Göran
-
Youngman, Linda
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Lehtinen, Matti
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
- Articles in the publication
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American Journal ...
- By the university
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Lund University
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Umeå University
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Karolinska Institutet