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Differences in Orig...
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Lambertsen, Kate L
(author)
Differences in Origin of Reactive Microglia in Bone Marrow Chimeric Mouse and Rat After Transient Global Ischemia.
- Article/chapterEnglish2011
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LIBRIS-ID:oai:lup.lub.lu.se:bfceca6f-54f0-414e-97c3-f24e7a997084
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https://lup.lub.lu.se/record/1972579URI
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https://doi.org/10.1097/NEN.0b013e31821db3aaDOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Current understanding of microglial involvement in disease is influenced by the observation that recruited bone marrow (BM)-derived cells contribute to reactive microgliosis in BM-chimeric mice. In contrast, a similar phenomenon has not been reported for BM-chimeric rats. We investigated the recruitment and microglial transformation of BM-derived cells in radiation BM-chimeric mice and rats after transientglobal cerebral ischemia, which elicits a characteristic microglialreaction. Both species displayed microglial hyperplasia and rod cell transformation in the hippocampal CA1 region. In mice, a subpopulation of lesion-reactive microglia originated from transformed BM-derived cells. By contrast, no recruitment or microglial transformation of BM-derived cells was observed in BM-chimeric rats. These results suggest that reactive microglia in rats originate from resident microglia, whereas they have a mixed BM-derived and resident origin in mice, depending on the severity of ischemic tissue damage.
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Deierborg, TomasLund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine(Swepub:lu)expb-tol
(author)
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Gregersen, Rikke
(author)
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Clausen, Bettina H
(author)
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Wirenfeldt, Martin
(author)
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Nielsen, Helle H
(author)
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Dalmau, Ishar
(author)
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Diemer, Nils H
(author)
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Dagnaes-Hansen, Frederik
(author)
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Johansen, Flemming F
(author)
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Keating, Armand
(author)
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Finsen, Bente
(author)
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Institutionen för experimentell medicinsk vetenskapMedicinska fakulteten
(creator_code:org_t)
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In:Journal of Neuropathology and Experimental Neurology70:6, s. 481-4941554-6578
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Lambertsen, Kate ...
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Deierborg, Tomas
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Gregersen, Rikke
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Clausen, Bettina ...
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Wirenfeldt, Mart ...
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Nielsen, Helle H
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Dalmau, Ishar
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Diemer, Nils H
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Dagnaes-Hansen, ...
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Johansen, Flemmi ...
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Keating, Armand
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Finsen, Bente
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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Journal of Neuro ...
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Lund University