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  • Lambertsen, Kate L (author)

Differences in Origin of Reactive Microglia in Bone Marrow Chimeric Mouse and Rat After Transient Global Ischemia.

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • 2011

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  • LIBRIS-ID:oai:lup.lub.lu.se:bfceca6f-54f0-414e-97c3-f24e7a997084
  • https://lup.lub.lu.se/record/1972579URI
  • https://doi.org/10.1097/NEN.0b013e31821db3aaDOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Current understanding of microglial involvement in disease is influenced by the observation that recruited bone marrow (BM)-derived cells contribute to reactive microgliosis in BM-chimeric mice. In contrast, a similar phenomenon has not been reported for BM-chimeric rats. We investigated the recruitment and microglial transformation of BM-derived cells in radiation BM-chimeric mice and rats after transientglobal cerebral ischemia, which elicits a characteristic microglialreaction. Both species displayed microglial hyperplasia and rod cell transformation in the hippocampal CA1 region. In mice, a subpopulation of lesion-reactive microglia originated from transformed BM-derived cells. By contrast, no recruitment or microglial transformation of BM-derived cells was observed in BM-chimeric rats. These results suggest that reactive microglia in rats originate from resident microglia, whereas they have a mixed BM-derived and resident origin in mice, depending on the severity of ischemic tissue damage.

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  • Deierborg, TomasLund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine(Swepub:lu)expb-tol (author)
  • Gregersen, Rikke (author)
  • Clausen, Bettina H (author)
  • Wirenfeldt, Martin (author)
  • Nielsen, Helle H (author)
  • Dalmau, Ishar (author)
  • Diemer, Nils H (author)
  • Dagnaes-Hansen, Frederik (author)
  • Johansen, Flemming F (author)
  • Keating, Armand (author)
  • Finsen, Bente (author)
  • Institutionen för experimentell medicinsk vetenskapMedicinska fakulteten (creator_code:org_t)

Related titles

  • In:Journal of Neuropathology and Experimental Neurology70:6, s. 481-4941554-6578

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