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Human G protein-cou...
Human G protein-coupled receptor GPR-9-6/CC chemokine receptor 9 is selectively expressed on intestinal homing T lymphocytes, mucosal lymphocytes, and thymocytes and is required for thymus-expressed chemokine-mediated chemotaxis
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Zabel, B A (author)
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- Agace, William (author)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups
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Campbell, J J (author)
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Heath, H M (author)
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Parent, D (author)
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Roberts, A I (author)
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Ebert, E C (author)
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Kassam, N (author)
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Qin, S (author)
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Zovko, M (author)
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LaRosa, G J (author)
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Yang, L L (author)
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Soler, D (author)
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Butcher, E C (author)
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Ponath, P D (author)
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Parker, C M (author)
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Andrew, D P (author)
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(creator_code:org_t)
- 1999
- 1999
- English.
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In: Journal of Experimental Medicine. - 1540-9538. ; 190:9, s. 1241-1256
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Abstract
Subject headings
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- TECK (thymus-expressed chemokine), a recently described CC chemokine expressed in thymus and small intestine, was found to mediate chemotaxis of human G protein-coupled receptor GPR-9-6/L1.2 transfectants. This activity was blocked by anti-GPR-9-6 monoclonal antibody (mAb) 3C3. GPR-9-6 is expressed on a subset of memory alpha4beta7(high) intestinal trafficking CD4 and CD8 lymphocytes. In addition, all intestinal lamina propria and intraepithelial lymphocytes express GPR-9-6. In contrast, GPR-9-6 is not displayed on cutaneous lymphocyte antigen-positive (CLA(+)) memory CD4 and CD8 lymphocytes, which traffic to skin inflammatory sites, or on other systemic alpha4beta7(-)CLA(-) memory CD4/CD8 lymphocytes. The majority of thymocytes also express GPR-9-6, but natural killer cells, monocytes, eosinophils, basophils, and neutrophils are GPR-9-6 negative. Transcripts of GPR-9-6 and TECK are present in both small intestine and thymus. Importantly, the expression profile of GPR-9-6 correlates with migration to TECK of blood T lymphocytes and thymocytes. As migration of these cells is blocked by anti-GPR-9-6 mAb 3C3, we conclude that GPR-9-6 is the principal chemokine receptor for TECK. In agreement with the nomenclature rules for chemokine receptors, we propose the designation CCR-9 for GPR-9-6. The selective expression of TECK and GPR-9-6 in thymus and small intestine implies a dual role for GPR-9-6/CCR-9, both in T cell development and the mucosal immune response.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- chemokine
- {alpha}4ß7
- cutaneous lymphocyte antigen
- memory
- intestinal
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Zabel, B A
-
Agace, William
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Campbell, J J
-
Heath, H M
-
Parent, D
-
Roberts, A I
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show more...
-
Ebert, E C
-
Kassam, N
-
Qin, S
-
Zovko, M
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LaRosa, G J
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Yang, L L
-
Soler, D
-
Butcher, E C
-
Ponath, P D
-
Parker, C M
-
Andrew, D P
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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Journal of Exper ...
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Lund University