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Longitudinal Metabo...
Longitudinal Metabolome-Wide Signals Prior to the Appearance of a First Islet Autoantibody in Children Participating in the TEDDY Study
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- Li, Qian (author)
- University of South Florida
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- Parikh, Hemang (author)
- University of South Florida
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- Butterworth, Martha D (author)
- University of South Florida
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- Lernmark, Åke (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital
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- Hagopian, William (author)
- Pacific Northwest Research Institute
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- Rewers, Marian (author)
- University of Colorado-Denver
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- She, Jin-Xiong (author)
- Medical College of Georgia
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- Toppari, Jorma (author)
- University of Turku,Turku University Hospital
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- Ziegler, Anette-G (author)
- Technical University of Munich,Helmholtz Zentrum München
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- Akolkar, Beena (author)
- National Institute of Diabetes and Digestive and Kidney Diseases
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- Fiehn, Oliver (author)
- University of California, Davis
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- Fan, Sili (author)
- University of California, Davis
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- Krischer, Jeffrey P (author)
- University of South Florida
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(creator_code:org_t)
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- 2020-02-13
- 2020
- English 12 s.
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In: Diabetes. - : American Diabetes Association. - 1939-327X .- 0012-1797. ; 69:3, s. 465-476
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http://dx.doi.org/10... (free)
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https://diabetes.dia...
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Abstract
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- Children at increased genetic risk for type 1 diabetes (T1D) after environmental exposures may develop pancreatic islet autoantibodies (IA) at a very young age. Metabolic profile changes over time may imply responses to exposures and signal development of the first IA. Our present research in The Environmental Determinants of Diabetes in the Young (TEDDY) study aimed to identify metabolome-wide signals preceding the first IA against GAD (GADA-first) or against insulin (IAA-first). We profiled metabolomes by mass spectrometry from children's plasma at 3-month intervals after birth until appearance of the first IA. A trajectory analysis discovered each first IA preceded by reduced amino acid proline and branched-chain amino acids (BCAAs), respectively. With independent time point analysis following birth, we discovered dehydroascorbic acid (DHAA) contributing to the risk of each first IA, and γ-aminobutyric acid (GABAs) associated with the first autoantibody against insulin (IAA-first). Methionine and alanine, compounds produced in BCAA metabolism and fatty acids, also preceded IA at different time points. Unsaturated triglycerides and phosphatidylethanolamines decreased in abundance before appearance of either autoantibody. Our findings suggest that IAA-first and GADA-first are heralded by different patterns of DHAA, GABA, multiple amino acids, and fatty acids, which may be important to primary prevention of T1D.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
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- art (subject category)
- ref (subject category)
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Diabetes
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- By the author/editor
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Li, Qian
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Parikh, Hemang
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Butterworth, Mar ...
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Lernmark, Åke
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Hagopian, Willia ...
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Rewers, Marian
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show more...
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She, Jin-Xiong
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Toppari, Jorma
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Ziegler, Anette- ...
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Akolkar, Beena
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Fiehn, Oliver
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Fan, Sili
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Krischer, Jeffre ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
- Articles in the publication
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Diabetes
- By the university
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Lund University