Search: onr:"swepub:oai:lup.lub.lu.se:c16c6ad9-7911-4d51-be86-d0078aec51dc" >
Impact of glucocort...
Impact of glucocorticoids on the incidence of lupus-related major organ damage : A systematic literature review and meta-regression analysis of longitudinal observational studies
-
- Ugarte-Gil, Manuel Francisco (author)
- Scientific University of the South, Lima,Hospital Nacional Guillermo Almenara Irigoyen, EsSalud
-
- Mak, Anselm (author)
- National University of Singapore,National University Health System
-
- Leong, Joanna (author)
- Changi General Hospital
-
show more...
-
- Dharmadhikari, Bhushan (author)
- National University of Singapore
-
- Kow, Nien Yee (author)
- National University of Singapore,National University Health System
-
- Reátegui-Sokolova, Cristina (author)
- San Ignacio De Loyola University (USIL),Hospital Nacional Guillermo Almenara Irigoyen, EsSalud
-
- Elera-Fitzcarrald, Claudia (author)
- Scientific University of the South, Lima,Hospital Nacional Guillermo Almenara Irigoyen, EsSalud
-
- Aranow, Cinthia (author)
- Feinstein Institute for Medical Research
-
- Arnaud, Laurent (author)
- University of Strasbourg
-
- Askanase, Anca D. (author)
- Columbia University
-
- Bae, Sang Cheol (author)
- Hanyang University Seoul Hospital
-
- Bernatsky, Sasha (author)
- McGill University
-
- Bruce, Ian N. (author)
- Centre for Epidemiology Versus Arthritis,Manchester University NHS Foundation Trust
-
- Buyon, Jill (author)
- NYU Grossman School of Medicine
-
- Costedoat-Chalumeau, Nathalie (author)
- Paris Diderot University,Centre of Epidemiology And Biostatistics Sorbonne Paris Cité Center (CRESS),Cochin Hospital
-
- Dooley, Mary Ann (author)
- University of North Carolina
-
- Fortin, Paul R. (author)
- Centre hospitalier universitaire de Québec
-
- Ginzler, Ellen M. (author)
- SUNY Downstate Health Sciences University,University of Pisa
-
- Gladman, Dafna D. (author)
- University of Toronto
-
- Hanly, John (author)
- Dalhousie University
-
- Inanc, Murat (author)
- Istanbul University
-
- Isenberg, David (author)
- University College London
-
- Jacobsen, Soren (author)
- Copenhagen University Hospital
-
- James, Judith A. (author)
- University of Oklahoma Health Sciences Center,Oklahoma Medical Research Foundation
-
- Jönsen, Andreas (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
-
- Kalunian, Kenneth (author)
- University of California, San Diego
-
- Kamen, Diane L. (author)
- Medical University of South Carolina
-
- Lim, Sung Sam (author)
- Emory University
-
- Morand, Eric (author)
- Monash University
-
- Mosca, Marta (author)
- University of Pisa
-
- Peschken, Christine (author)
- University of Manitoba
-
- Pons-Estel, Bernardo A. (author)
- Grupo Oroño-Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR)
-
- Rahman, Anisur (author)
- University College London
-
- Ramsey-Goldman, Rosalind (author)
- Northwestern University Feinberg School of Medicine
-
- Reynolds, John (author)
- University of Birmingham,City Hospital, Birmingham
-
- Romero-Diaz, Juanita (author)
- Salvador Zubirán National Institute of Health Sciences and Nutrition
-
- Ruiz-Irastorza, Guillermo (author)
- University of the Basque Country
-
- Sánchez-Guerrero, Jorge (author)
- Mount Sinai Hospital of University of Toronto
-
- Svenungsson, Elisabet (author)
- Karolinska Institutet,Karolinska University Hospital
-
- Urowitz, Murray (author)
- University of Toronto
-
- Vinet, Evelyne (author)
- McGill University
-
- Van Vollenhoven, Ronald F. (author)
- Academic Medical Center of University of Amsterdam (AMC)
-
- Voskuyl, Alexandre (author)
- Vrije Universiteit Amsterdam
-
- Wallace, Daniel J. (author)
- University of California, Los Angeles,Cedars-Sinai Medical Center
-
- Petri, Michelle A. (author)
- Johns Hopkins University School of Medicine
-
- Manzi, Susan (author)
- Allegheny Health Network
-
- Clarke, Ann Elaine (author)
- Cumming School of Medicine
-
- Cheung, Mike (author)
- National University of Singapore
-
- Farewell, Vernon (author)
- University of Cambridge
-
- Alarcon, Graciela S. (author)
- University of Alabama,Cayetano Heredia University
-
show less...
-
(creator_code:org_t)
- 2021-12-20
- 2021
- English.
-
In: Lupus Science and Medicine. - : BMJ. - 2053-8790. ; 8:1
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://lupus.bmj.co...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Objective In systemic lupus erythematosus (SLE), disease activity and glucocorticoid (GC) exposure are known to contribute to irreversible organ damage. We aimed to examine the association between GC exposure and organ damage occurrence. Methods We conducted a literature search (PubMed (Medline), Embase and Cochrane January 1966-October 2021). We identified original longitudinal observational studies reporting GC exposure as the proportion of users and/or GC use with dose information as well as the occurrence of new major organ damage as defined in the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index. Meta-regression analyses were performed. Reviews, case-reports and studies with <5 years of follow-up, <50 patients, different outcomes and special populations were excluded. Results We selected 49 articles including 16 224 patients, 14 755 (90.9%) female with a mean age and disease duration of 35.1 years and of 37.1 months. The mean follow-up time was 104.9 months. For individual damage items, the average daily GC dose was associated with the occurrence of overall cardiovascular events and with osteoporosis with fractures. A higher average cumulative dose adjusted (or not)/number of follow-up years and a higher proportion of patients on GC were associated with the occurrence of osteonecrosis. Conclusions We confirm associations of GC use with three specific damage items. In treating patients with SLE, our aim should be to maximise the efficacy of GC and to minimise their harms.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- glucocorticoids
- health care
- lupus erythematosus
- outcome assessment
- systemic
Publication and Content Type
- for (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Ugarte-Gil, Manu ...
-
Mak, Anselm
-
Leong, Joanna
-
Dharmadhikari, B ...
-
Kow, Nien Yee
-
Reátegui-Sokolov ...
-
show more...
-
Elera-Fitzcarral ...
-
Aranow, Cinthia
-
Arnaud, Laurent
-
Askanase, Anca D ...
-
Bae, Sang Cheol
-
Bernatsky, Sasha
-
Bruce, Ian N.
-
Buyon, Jill
-
Costedoat-Chalum ...
-
Dooley, Mary Ann
-
Fortin, Paul R.
-
Ginzler, Ellen M ...
-
Gladman, Dafna D ...
-
Hanly, John
-
Inanc, Murat
-
Isenberg, David
-
Jacobsen, Soren
-
James, Judith A.
-
Jönsen, Andreas
-
Kalunian, Kennet ...
-
Kamen, Diane L.
-
Lim, Sung Sam
-
Morand, Eric
-
Mosca, Marta
-
Peschken, Christ ...
-
Pons-Estel, Bern ...
-
Rahman, Anisur
-
Ramsey-Goldman, ...
-
Reynolds, John
-
Romero-Diaz, Jua ...
-
Ruiz-Irastorza, ...
-
Sánchez-Guerrero ...
-
Svenungsson, Eli ...
-
Urowitz, Murray
-
Vinet, Evelyne
-
Van Vollenhoven, ...
-
Voskuyl, Alexand ...
-
Wallace, Daniel ...
-
Petri, Michelle ...
-
Manzi, Susan
-
Clarke, Ann Elai ...
-
Cheung, Mike
-
Farewell, Vernon
-
Alarcon, Graciel ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Rheumatology and ...
- Articles in the publication
-
Lupus Science an ...
- By the university
-
Lund University
-
Karolinska Institutet