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Association between...
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Perez-Martinez, Pablo
(author)
Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states
- Article/chapterEnglish2009
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LIBRIS-ID:oai:lup.lub.lu.se:c27414e5-2db9-4dd8-9181-f0cf73ecf1c0
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https://lup.lub.lu.se/record/1313544URI
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https://doi.org/10.3945/ajcn.2008.26363DOI
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Language:English
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Summary in:English
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Background: Hypertriglyceridemia is a risk factor for cardiovascular disease. Variation in the apolipoprotein A5 (APOA5) and glucokinase regulatory protein (GCKR) genes has been associated with fasting plasma triacylglycerol. Objective: We investigated the combined effects of the GCKR rs780094C -> T, APOA5 -1131T -> C, and APOA5 56C -> G single nucleotide polymorphisms (SNPs) on fasting triacylglycerol in several independent populations and the response to a high-fat meal and fenofibrate interventions. Design: We used a cross-sectional design to investigate the association with fasting triacylglycerol in 8 populations from America, Asia, and Europe (n = 7730 men and women) and 2 intervention studies in US whites (n = `1061) to examine postprandial triacylglycerol after a high-fat meal and the response to fenofibrate. We defined 3 combined genotype groups: 1) protective (homozygous for the wild-type allele for all 3 SNPs); 2) intermediate (any mixed genotype not included in groups 1 and 3); and 3) risk (carriers of the variant alleles at both genes). Results: Subjects within the risk group had significantly higher fasting triacylglycerol and a higher prevalence of hypertriglyceridemia than did subjects in the protective group across all populations. Moreover, subjects in the risk group had a greater postprandial triacylglycerol response to a high-fat meal and greater fenofibrate-induced reduction of fasting triacylglycerol than did the other groups, especially among persons with hypertriglyceridemia. Subjects with the intermediate genotype had intermediate values (P for trend < 0.001). Conclusions: SNPs in GCKR and APOA5 have an additive effect on both fasting and postprandial triacylglycerol and contribute to the interindividual variability in response to fenofibrate treatment. Am J Clin Nutr 2009;89:391-9. Clin Nutr 2009; 89: 391-9.
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Corella, Dolores
(author)
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Shen, Jian
(author)
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Arnett, Donna K.
(author)
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Yiannakouris, Nikos
(author)
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Tai, E. Syong
(author)
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Orho-Melander, MarjuLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-mor
(author)
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Tucker, Katherine L.
(author)
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Tsai, Michael
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Straka, Robert J.
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Province, Michael
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Kai, Chew Suok
(author)
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Perez-Jimenez, Francisco
(author)
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Lai, Chao-Qiang
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Lopez-Miranda, Jose
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Guillen, Marisa
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Parnell, Laurence D.
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Borecki, Ingrid
(author)
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Kathiresan, Sekar
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Ordovas, Jose M.
(author)
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Genomik, diabetes och endokrinologiForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:American Journal of Clinical Nutrition: Elsevier BV89:1, s. 391-3991938-32070002-9165
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Tai, E. Syong
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