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  • Perez-Martinez, Pablo (author)

Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • Elsevier BV,2009

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  • LIBRIS-ID:oai:lup.lub.lu.se:c27414e5-2db9-4dd8-9181-f0cf73ecf1c0
  • https://lup.lub.lu.se/record/1313544URI
  • https://doi.org/10.3945/ajcn.2008.26363DOI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Background: Hypertriglyceridemia is a risk factor for cardiovascular disease. Variation in the apolipoprotein A5 (APOA5) and glucokinase regulatory protein (GCKR) genes has been associated with fasting plasma triacylglycerol. Objective: We investigated the combined effects of the GCKR rs780094C -> T, APOA5 -1131T -> C, and APOA5 56C -> G single nucleotide polymorphisms (SNPs) on fasting triacylglycerol in several independent populations and the response to a high-fat meal and fenofibrate interventions. Design: We used a cross-sectional design to investigate the association with fasting triacylglycerol in 8 populations from America, Asia, and Europe (n = 7730 men and women) and 2 intervention studies in US whites (n = `1061) to examine postprandial triacylglycerol after a high-fat meal and the response to fenofibrate. We defined 3 combined genotype groups: 1) protective (homozygous for the wild-type allele for all 3 SNPs); 2) intermediate (any mixed genotype not included in groups 1 and 3); and 3) risk (carriers of the variant alleles at both genes). Results: Subjects within the risk group had significantly higher fasting triacylglycerol and a higher prevalence of hypertriglyceridemia than did subjects in the protective group across all populations. Moreover, subjects in the risk group had a greater postprandial triacylglycerol response to a high-fat meal and greater fenofibrate-induced reduction of fasting triacylglycerol than did the other groups, especially among persons with hypertriglyceridemia. Subjects with the intermediate genotype had intermediate values (P for trend < 0.001). Conclusions: SNPs in GCKR and APOA5 have an additive effect on both fasting and postprandial triacylglycerol and contribute to the interindividual variability in response to fenofibrate treatment. Am J Clin Nutr 2009;89:391-9. Clin Nutr 2009; 89: 391-9.

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  • Corella, Dolores (author)
  • Shen, Jian (author)
  • Arnett, Donna K. (author)
  • Yiannakouris, Nikos (author)
  • Tai, E. Syong (author)
  • Orho-Melander, MarjuLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-mor (author)
  • Tucker, Katherine L. (author)
  • Tsai, Michael (author)
  • Straka, Robert J. (author)
  • Province, Michael (author)
  • Kai, Chew Suok (author)
  • Perez-Jimenez, Francisco (author)
  • Lai, Chao-Qiang (author)
  • Lopez-Miranda, Jose (author)
  • Guillen, Marisa (author)
  • Parnell, Laurence D. (author)
  • Borecki, Ingrid (author)
  • Kathiresan, Sekar (author)
  • Ordovas, Jose M. (author)
  • Genomik, diabetes och endokrinologiForskargrupper vid Lunds universitet (creator_code:org_t)

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  • In:American Journal of Clinical Nutrition: Elsevier BV89:1, s. 391-3991938-32070002-9165

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