Randomized Controlled Early versus Late Ventricular Intervention Study in Posthemorrhagic Ventricular Dilatation : Outcome at 2 Years

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: onr:"swepub:oai:lup.lub.lu.se:c32c7b66-4c20-4844-bede-a7f3fa848608" > Randomized Controll...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Cizmeci, Mehmet NUniversity of Toronto (author)

Randomized Controlled Early versus Late Ventricular Intervention Study in Posthemorrhagic Ventricular Dilatation : Outcome at 2 Years

Article/chapterEnglish2020

Publisher, publication year, extent ...

Elsevier BV,2020

Numbers

LIBRIS-ID:oai:lup.lub.lu.se:c32c7b66-4c20-4844-bede-a7f3fa848608
https://lup.lub.lu.se/record/c32c7b66-4c20-4844-bede-a7f3fa848608URI
https://doi.org/10.1016/j.jpeds.2020.08.014DOI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

Notes

OBJECTIVE: To compare the effect of intervention at low vs high threshold of ventriculomegaly in preterm infants with posthemorrhagic ventricular dilatation on death or severe neurodevelopmental disability.STUDY DESIGN: This multicenter randomized controlled trial reviewed lumbar punctures initiated after either a low threshold (ventricular index of >p97 and anterior horn width of >6 mm) or high threshold (ventricular index of >p97 + 4 mm and anterior horn width of >10 mm). The composite adverse outcome was defined as death or cerebral palsy or Bayley composite cognitive/motor scores <-2 SDs at 24 months corrected age.RESULTS: Outcomes were assessed in 113 of 126 infants. The composite adverse outcome was seen in 20 of 58 infants (35%) in the low threshold group and 28 of 55 (51%) in the high threshold (P = .07). The low threshold intervention was associated with a decreased risk of an adverse outcome after correcting for gestational age, severity of intraventricular hemorrhage, and cerebellar hemorrhage (aOR, 0.24; 95% CI, 0.07-0.87; P = .03). Infants with a favorable outcome had a smaller fronto-occipital horn ratio (crude mean difference, -0.06; 95% CI, -0.09 to -0.03; P < .001) at term-equivalent age. Infants in the low threshold group with a ventriculoperitoneal shunt, had cognitive and motor scores similar to those without (P = .3 for both), whereas in the high threshold group those with a ventriculoperitoneal shunt had significantly lower scores than those without a ventriculoperitoneal shunt (P = .01 and P = .004, respectively).CONCLUSIONS: In a post hoc analysis, earlier intervention was associated with a lower odds of death or severe neurodevelopmental disability in preterm infants with progressive posthemorrhagic ventricular dilatation.TRIAL REGISTRATION: ISRCTN43171322.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Pediatrik hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Pediatrics hsv//eng
Cerebral Hemorrhage/complications
Cerebral Ventricles/pathology
Child, Preschool
Cohort Studies
Dilatation, Pathologic
Female
Humans
Infant
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases/psychology
Male
Neurodevelopmental Disorders/diagnosis
Spinal Puncture
Time-to-Treatment
Ventriculoperitoneal Shunt

Added entries (persons, corporate bodies, meetings, titles ...)

Groenendaal, FlorisErasmus University Medical Center (author)
Liem, Kian DRadboud University Medical Center (author)
van Haastert, Ingrid CErasmus University Medical Center (author)
Benavente-Fernández, IsabelPuerta del Mar University Hospital (author)
van Straaten, Henrica L MIsala Women and Children's Hospital (author)
Steggerda, SylkeLeiden University Medical Centre (author)
Smit, Bert JErasmus University Medical Center (author)
Whitelaw, AndrewUniversity of Bristol (author)
Woerdeman, PeterUniversity Medical Center Utrecht (author)
Heep, AxelUniversity of Bristol (author)
de Vries, Linda SErasmus University Medical Center (author)
Ley, DavidLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neonatologi,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Neonatology,Lund University Research Groups(Swepub:lu)pedi-dle (creator_code:cre_t)
Fellman, VinetaLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)pedi-vfe (creator_code:cre_t)
University of TorontoErasmus University Medical Center (creator_code:org_t)
ELVIS study group

Related titles

In:Journal of Pediatrics: Elsevier BV226, s. 3-351097-68330022-3476

Internet link

Find in a library

Journal of Pediatrics (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Cizmeci, Mehmet ...; Groenendaal, Flo ...; Liem, Kian D; van Haastert, In ...; Benavente-Fernán ...; van Straaten, He ...; show more...; Steggerda, Sylke; Smit, Bert J; Whitelaw, Andrew; Woerdeman, Peter; Heep, Axel; de Vries, Linda ...; Ley, David; Fellman, Vineta; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Pediatrics

Articles in the publication: Journal of Pedia ...

By the university: Lund University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se