Search: onr:"swepub:oai:lup.lub.lu.se:c33cfbd3-0a56-4a90-a485-5091051caa1c" >
Alterations in regu...
Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B-null mice
- Article/chapterEnglish2006
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:lup.lub.lu.se:c33cfbd3-0a56-4a90-a485-5091051caa1c
-
https://lup.lub.lu.se/record/683632URI
-
https://doi.org/10.1172/JCI24867DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:art swepub-publicationtype
-
Subject category:ref swepub-contenttype
Notes
-
Cyclic nucleotide phosphodiesterase 3B (PDE3B) has been suggested to be critical for mediating insulin/IGF-1 inhibition of cAMP signaling in adipocytes, liver, and pancreatic beta cells. In Pde3b-KO adipocytes we found decreased adipocyte size, unchanged insulin-stimulated phosphorylation of protein kinase B and activation of glucose uptake, enhanced catecholamine-stimulated lipolysis and insulin-stimulated hpogenesis, and blocked insulin inhibition of catecholamine-stimulated lipolysis. Glucose, alone or in combination with glucagon-like peptide-1, increased insulin secretion more in isolated pancreatic KO islets, although islet size and morphology and immunoreactive insulin and glucagon levels were unchanged. The beta(3)-adrenergic agonist CL 316,243 (CL) increased lipolysis and serum insulin more in KO mice, but blood glucose reduction was less in CL-treated KO mice. Insulin resistance was observed in KO mice, with liver an important site of alterations in insulin-sensitive glucose production. In KO mice, liver triglyceride and cAMP contents were increased, and the liver content and phosphorylation states of several insulin signaling, gluconeogenic, and inflammation- and stress-related components were altered. Thus, PDE3B may be important in regulating certain cAMP signaling pathways, including lipolysis, insulin-induced antilipolysis, and cAMP-mediated insulin secretion. Altered expression and/or regulation of PDE3B may contribute to metabolic dysregulation, including systemic insulin resistance.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Park, Sunhee
(author)
-
Hockman, Steven
(author)
-
Zmuda-Trzebiatowska, Emilia
(author)
-
Svennelid, FredrikLund University,Lunds universitet,Biokemi och Strukturbiologi,Centrum för Molekylär Proteinvetenskap,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biochemistry and Structural Biology,Center for Molecular Protein Science,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)pbio-fsv
(author)
-
Haluzik, Martin
(author)
-
Gavrilova, Oksana
(author)
-
Ahmad, Faiyaz
(author)
-
Pepin, Laurent
(author)
-
Napolitano, Maria
(author)
-
Taira, Masato
(author)
-
Sundler, FrankLund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine(Swepub:lu)mphy-fsu
(author)
-
Stenson, LenaLund University,Lunds universitet,Signaltransduktionsforskning,Forskargrupper vid Lunds universitet,Insulin Signal Transduction,Lund University Research Groups(Swepub:lu)medk-lsh
(author)
-
Degerman, EvaLund University,Lunds universitet,Signaltransduktionsforskning,Forskargrupper vid Lunds universitet,Insulin Signal Transduction,Lund University Research Groups(Swepub:lu)medk-ede
(author)
-
Manganiello, Vincent C.
(author)
-
Biokemi och StrukturbiologiCentrum för Molekylär Proteinvetenskap
(creator_code:org_t)
Related titles
-
In:Journal of Clinical Investigation116:12, s. 3240-32510021-9738
Internet link
Find in a library
To the university's database
- By the author/editor
-
Choi, Young Hun
-
Park, Sunhee
-
Hockman, Steven
-
Zmuda-Trzebiatow ...
-
Svennelid, Fredr ...
-
Haluzik, Martin
-
show more...
-
Gavrilova, Oksan ...
-
Ahmad, Faiyaz
-
Pepin, Laurent
-
Napolitano, Mari ...
-
Taira, Masato
-
Sundler, Frank
-
Stenson, Lena
-
Degerman, Eva
-
Manganiello, Vin ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
- Articles in the publication
-
Journal of Clini ...
- By the university
-
Lund University