Search: onr:"swepub:oai:lup.lub.lu.se:c365e068-ffe7-4da6-84bb-f3ba3e729621" >
Krebs von den Lunge...
-
Stockhammer, PaulRuhrlandklinik
(author)
Krebs von den Lungen 6 (KL-6) is a novel diagnostic and prognostic biomarker in pleural mesothelioma
- Article/chapterEnglish2023
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:lup.lub.lu.se:c365e068-ffe7-4da6-84bb-f3ba3e729621
-
https://lup.lub.lu.se/record/c365e068-ffe7-4da6-84bb-f3ba3e729621URI
-
https://doi.org/10.1016/j.lungcan.2023.107360DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:art swepub-publicationtype
-
Subject category:ref swepub-contenttype
Notes
-
Objectives: Pleural mesothelioma (PM) is a rare disease with dismal outcome. Systemic treatment options include chemotherapy and immunotherapy, but biomarkers for treatment personalization are missing. The only FDA-approved diagnostic biomarker is the soluble mesothelin-related protein (SMRP). Krebs von den Lungen-6 (KL-6) is a human mucin 1 (MUC1) glycoprotein, which has shown diagnostic and prognostic value as a biomarker in other malignancies. The present study investigated whether KL-6 can serve as a diagnostic and/or prognostic biomarker in PM. Materials and methods: Using a fully-automated chemiluminescence enzyme immunoassay (CLEIA) for KL-6 and SMRP, pleural effusion samples from 87 consecutive patients with PM and 25 patients with non-malignant pleural disorders were studied. In addition, KL-6 and SMRP levels were determined in corresponding patient sera, and in an independent validation cohort (n = 122). MUC1 mRNA and protein expression, and KL-6 levels in cell line supernatants were investigated in PM primary cell lines in vitro. Results: PM patients had significantly higher KL-6 levels in pleural effusion than non-malignant controls (AUC 0.78, p < 0.0001). Among PM patients, levels were highest in those with epithelioid or biphasic histologies. There was a strong positive correlation between pleural effusion levels of KL-6 and SMRP (p < 0.0001). KL-6 levels in sera similarly associated with diagnosis of PM, however, to a lesser extent (AUC 0.71, p = 0.008). PM patients with high pleural effusion KL-6 levels (≥303 IU/mL) had significantly better overall survival (OS) compared to those with low KL-6 levels (HR 0.51, p = 0.004). Congruently, high tumor cell MUC1 mRNA expression in primary cell lines associated with prolonged corresponding patient OS (HR 0.35, p = 0.004). These findings were confirmed in an independent validation cohort. Conclusion: This is the first study demonstrating KL-6 as a potential novel liquid-based diagnostic and prognostic biomarker in PM.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Baumeister, HannahRuhrlandklinik
(author)
-
Ploenes, TillRuhrlandklinik
(author)
-
Bonella, FrancescoRuhrlandklinik
(author)
-
Theegarten, DirkUniversity Hospital Essen
(author)
-
Dome, BalazsLund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups,Semmelweis University,National Korányi Institute for Tuberculosis and Pulmonology, Hungary,Medical University of Vienna(Swepub:lu)ba1464do
(author)
-
Pirker, ChristineMedical University of Vienna
(author)
-
Berger, WalterMedical University of Vienna
(author)
-
Hegedüs, LucaRuhrlandklinik
(author)
-
Baranyi, MarcellSemmelweis University
(author)
-
Schuler, MartinUniversity Hospital Essen
(author)
-
Deshayes, SophieUniversity of Nantes
(author)
-
Bölükbas, ServetRuhrlandklinik
(author)
-
Aigner, ClemensUniversity Hospital Essen,Ruhrlandklinik
(author)
-
Blanquart, ChristopheUniversity of Nantes
(author)
-
Hegedüs, BalazsRuhrlandklinik
(author)
-
RuhrlandklinikUniversity Hospital Essen
(creator_code:org_t)
Related titles
-
In:Lung Cancer1850169-5002
Internet link
Find in a library
To the university's database
- By the author/editor
-
Stockhammer, Pau ...
-
Baumeister, Hann ...
-
Ploenes, Till
-
Bonella, Frances ...
-
Theegarten, Dirk
-
Dome, Balazs
-
show more...
-
Pirker, Christin ...
-
Berger, Walter
-
Hegedüs, Luca
-
Baranyi, Marcell
-
Schuler, Martin
-
Deshayes, Sophie
-
Bölükbas, Servet
-
Aigner, Clemens
-
Blanquart, Chris ...
-
Hegedüs, Balazs
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Clinical Laborat ...
- Articles in the publication
-
Lung Cancer
- By the university
-
Lund University