SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:lup.lub.lu.se:c365e068-ffe7-4da6-84bb-f3ba3e729621"
 

Search: onr:"swepub:oai:lup.lub.lu.se:c365e068-ffe7-4da6-84bb-f3ba3e729621" > Krebs von den Lunge...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Stockhammer, PaulRuhrlandklinik (author)

Krebs von den Lungen 6 (KL-6) is a novel diagnostic and prognostic biomarker in pleural mesothelioma

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • 2023

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:c365e068-ffe7-4da6-84bb-f3ba3e729621
  • https://lup.lub.lu.se/record/c365e068-ffe7-4da6-84bb-f3ba3e729621URI
  • https://doi.org/10.1016/j.lungcan.2023.107360DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Objectives: Pleural mesothelioma (PM) is a rare disease with dismal outcome. Systemic treatment options include chemotherapy and immunotherapy, but biomarkers for treatment personalization are missing. The only FDA-approved diagnostic biomarker is the soluble mesothelin-related protein (SMRP). Krebs von den Lungen-6 (KL-6) is a human mucin 1 (MUC1) glycoprotein, which has shown diagnostic and prognostic value as a biomarker in other malignancies. The present study investigated whether KL-6 can serve as a diagnostic and/or prognostic biomarker in PM. Materials and methods: Using a fully-automated chemiluminescence enzyme immunoassay (CLEIA) for KL-6 and SMRP, pleural effusion samples from 87 consecutive patients with PM and 25 patients with non-malignant pleural disorders were studied. In addition, KL-6 and SMRP levels were determined in corresponding patient sera, and in an independent validation cohort (n = 122). MUC1 mRNA and protein expression, and KL-6 levels in cell line supernatants were investigated in PM primary cell lines in vitro. Results: PM patients had significantly higher KL-6 levels in pleural effusion than non-malignant controls (AUC 0.78, p < 0.0001). Among PM patients, levels were highest in those with epithelioid or biphasic histologies. There was a strong positive correlation between pleural effusion levels of KL-6 and SMRP (p < 0.0001). KL-6 levels in sera similarly associated with diagnosis of PM, however, to a lesser extent (AUC 0.71, p = 0.008). PM patients with high pleural effusion KL-6 levels (≥303 IU/mL) had significantly better overall survival (OS) compared to those with low KL-6 levels (HR 0.51, p = 0.004). Congruently, high tumor cell MUC1 mRNA expression in primary cell lines associated with prolonged corresponding patient OS (HR 0.35, p = 0.004). These findings were confirmed in an independent validation cohort. Conclusion: This is the first study demonstrating KL-6 as a potential novel liquid-based diagnostic and prognostic biomarker in PM.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Baumeister, HannahRuhrlandklinik (author)
  • Ploenes, TillRuhrlandklinik (author)
  • Bonella, FrancescoRuhrlandklinik (author)
  • Theegarten, DirkUniversity Hospital Essen (author)
  • Dome, BalazsLund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups,Semmelweis University,National Korányi Institute for Tuberculosis and Pulmonology, Hungary,Medical University of Vienna(Swepub:lu)ba1464do (author)
  • Pirker, ChristineMedical University of Vienna (author)
  • Berger, WalterMedical University of Vienna (author)
  • Hegedüs, LucaRuhrlandklinik (author)
  • Baranyi, MarcellSemmelweis University (author)
  • Schuler, MartinUniversity Hospital Essen (author)
  • Deshayes, SophieUniversity of Nantes (author)
  • Bölükbas, ServetRuhrlandklinik (author)
  • Aigner, ClemensUniversity Hospital Essen,Ruhrlandklinik (author)
  • Blanquart, ChristopheUniversity of Nantes (author)
  • Hegedüs, BalazsRuhrlandklinik (author)
  • RuhrlandklinikUniversity Hospital Essen (creator_code:org_t)

Related titles

  • In:Lung Cancer1850169-5002

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view