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Enhanced predictive...
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Pareek, MananOdense University Hospital,Brigham and Women's Hospital / Harvard Medical School
(author)
Enhanced predictive capability of a 1-hour oral glucose tolerance test : A prospective population-based cohort study
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2017-11-14
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American Diabetes Association,2018
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7 s.
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LIBRIS-ID:oai:lup.lub.lu.se:c425b721-e539-4e88-8475-dd9c4af51632
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https://lup.lub.lu.se/record/c425b721-e539-4e88-8475-dd9c4af51632URI
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https://doi.org/10.2337/dc17-1351DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
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OBJECTIVE To examine whether the 1-h blood glucose measurement would be a more suitable screening tool for assessing the risk of diabetes and its complications than the 2-h measurement. RESEARCH DESIGN AND METHODS We conducted a prospective population-based cohort study of 4,867men, randomly selected fromprespecified birth cohorts between 1921 and 1949,who underwent an oral glucose tolerance test with blood glucose measurements at 0, 1, and 2 h. Subjects were followed for up to 39 years, with registry-based recording of events. Discriminative abilities of elevated 1-h (≥8.6 mmol/L) versus 2-h (≥7.8 mmol/L) glucose for predicting incident type 2 diabetes, vascular complications, andmortality were compared using Kaplan-Meier analysis, Cox proportional hazards regression, and net reclassification improvement. RESULTS Median agewas 48 years (interquartile range [IQR] 48-49). During follow-up (median 33 years [IQR 24-37]), 636 (13%) developed type 2 diabetes. Elevated 1-h glucose was associatedwith incident diabetes (hazard ratio 3.40 [95% CI 2.90-3.98], P < 0.001) and provided better risk assessment than impaired glucose tolerance (Harrell concordance index 0.637 vs. 0.511, P < 0.001). Addition of a 1-hmeasurement in subjects stratified by fasting glucose provided greater net reclassification improvement than the addition of a 2-h measurement (0.214 vs. 0.016, respectively). Finally, the 1-h glucose was significantly associated with vascular complications and mortality. CONCLUSIONS The 1-h blood glucose level is a stronger predictor of future type 2 diabetes than the 2-h level and is associated with diabetes complications and mortality.
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Bhatt, Deepak L.Brigham and Women's Hospital / Harvard Medical School
(author)
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Nielsen, Mette L.Odense University Hospital
(author)
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Jagannathan, RamNew York University
(author)
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Eriksson, Karl FredrikLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)medf-ker
(author)
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Nilsson, Peter M.Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)medf-pni
(author)
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Bergman, MichaelNew York University
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Olsen, Michael H.Odense University Hospital
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Odense University HospitalBrigham and Women's Hospital / Harvard Medical School
(creator_code:org_t)
Related titles
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In:Diabetes Care: American Diabetes Association41:1, s. 171-1770149-59921935-5548
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