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KIR B haplotype don...
KIR B haplotype donors confer a reduced risk of relapse after haploidentical transplantation in children with acute lymphoblastic leukemia.
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Oevermann, Lena (author)
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Michaelis, Sebastian U (author)
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Mezger, Markus (author)
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Lang, Peter (author)
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- Toporski, Jacek (author)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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Bertaina, Alice (author)
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Zecca, Marco (author)
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Moretta, Lorenzo (author)
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Locatelli, Franco (author)
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Handgretinger, Rupert (author)
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(creator_code:org_t)
- American Society of Hematology, 2014
- 2014
- English.
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In: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 124:17, s. 2744-2747
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Abstract
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- We analyzed the influence of donor killer-cell immunoglobulin-like receptor (KIR) gene haplotypes on the risk of relapse and probability of event-free survival (EFS) in children with acute lymphoblastic leukemia (ALL) who received HLA-haploidentical transplantation of ex vivo T-cell depleted peripheral blood stem cells. The KIR gene haplotype was evaluated in 85 donors and the KIR B-content score was determined in the 63 KIR haplotype-B donors. Patients transplanted from a KIR haplotype-B donor had a significantly better EFS than those transplanted from a KIR A-donor (50.6% versus 29.5%, respectively, p=0.033). Moreover, a high donor KIR B-content score was associated with a significantly reduced risk of relapse (Log-rank test for trend p=0.026). These data indicate that KIR genotyping should be included in the donor selection algorithm for haploidentical transplantation in children with ALL with the aim of choosing, whenever possible, a KIR haplotype-B donor with a high KIR B-content score.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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Blood
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- By the author/editor
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Oevermann, Lena
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Michaelis, Sebas ...
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Mezger, Markus
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Lang, Peter
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Toporski, Jacek
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Bertaina, Alice
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show more...
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Zecca, Marco
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Moretta, Lorenzo
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Locatelli, Franc ...
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Handgretinger, R ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Blood
- By the university
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Lund University