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Prediction of Breas...
Prediction of Breast Cancer Risk Based on Profiling With Common Genetic Variants
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Mavaddat, Nasim (author)
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Pharoah, Paul D. P. (author)
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Michailidou, Kyriaki (author)
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show more...
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Tyrer, Jonathan (author)
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Brook, Mark N. (author)
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Bolla, Manjeet K. (author)
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Wang, Qin (author)
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Dennis, Joe (author)
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Dunning, Alison M. (author)
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Shah, Mitul (author)
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Luben, Robert (author)
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Brown, Judith (author)
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Bojesen, Stig E. (author)
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Nordestgaard, Borge G. (author)
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Nielsen, Sune F. (author)
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Flyger, Henrik (author)
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- Czene, Kamila (author)
- Karolinska Institutet
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Darabi, Hatef (author)
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- Eriksson, Mikael (author)
- Karolinska Institutet
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Peto, Julian (author)
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dos-Santos-Silva, Isabel (author)
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Dudbridge, Frank (author)
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Johnson, Nichola (author)
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Schmidt, Marjanka K. (author)
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Broeks, Annegien (author)
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Verhoef, Senno (author)
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Rutgers, Emiel J. (author)
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Swerdlow, Anthony (author)
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- Ashworth, Alan (author)
- Karolinska Institutet
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Orr, Nick (author)
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Schoemaker, Minouk J. (author)
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Figueroa, Jonine (author)
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Chanock, Stephen J. (author)
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Brinton, Louise (author)
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Lissowska, Jolanta (author)
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Couch, Fergus J. (author)
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Olson, Janet E. (author)
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Vachon, Celine (author)
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Pankratz, Vernon S. (author)
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Lambrechts, Diether (author)
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Wildiers, Hans (author)
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Van Ongeval, Chantal (author)
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Van Limbergen, Erik (author)
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Kristensen, Vessela (author)
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Alnaes, Grethe Grenaker (author)
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Nord, Silje (author)
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Borresen-Dale, Anne-Lise (author)
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Nevanlinna, Heli (author)
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Muranen, Taru A. (author)
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Aittomaeki, Kristiina (author)
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Blomqvist, Carl (author)
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Chang-Claude, Jenny (author)
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Rudolph, Anja (author)
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Seibold, Petra (author)
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Flesch-Janys, Dieter (author)
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Fasching, Peter A. (author)
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Haeberle, Lothar (author)
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Ekici, Arif B. (author)
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Beckmann, Matthias W. (author)
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Burwinkel, Barbara (author)
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Marme, Frederik (author)
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Schneeweiss, Andreas (author)
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Sohn, Christof (author)
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Trentham-Dietz, Amy (author)
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Newcomb, Polly (author)
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Titus, Linda (author)
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Egan, Kathleen M. (author)
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Hunter, David J. (author)
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Lindstrom, Sara (author)
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Tamimi, Rulla M. (author)
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Kraft, Peter (author)
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Rahman, Nazneen (author)
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Turnbull, Clare (author)
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Renwick, Anthony (author)
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- Seal, Sheila (author)
- Karolinska Institutet
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Li, Jingmei (author)
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Liu, Jianjun (author)
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- Humphreys, Keith (author)
- Karolinska Institutet
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Benitez, Javier (author)
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Zamora, M. Pilar (author)
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Perez, Jose Ignacio Arias (author)
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Menendez, Primitiva (author)
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Jakubowska, Anna (author)
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Lubinski, Jan (author)
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Jaworska-Bieniek, Katarzyna (author)
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Durda, Katarzyna (author)
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Bogdanova, Natalia V. (author)
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Antonenkova, Natalia N. (author)
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Doerk, Thilo (author)
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Anton-Culver, Hoda (author)
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Neuhausen, Susan L. (author)
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Ziogas, Argyrios (author)
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Bernstein, Leslie (author)
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Devilee, Peter (author)
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Tollenaar, Robert A. E. M. (author)
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Seynaeve, Caroline (author)
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van Asperen, Christi J. (author)
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Cox, Angela (author)
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Cross, Simon S. (author)
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Reed, Malcolm W. R. (author)
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Khusnutdinova, Elza (author)
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Bermisheva, Marina (author)
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Prokofyeva, Darya (author)
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Takhirova, Zalina (author)
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Meindl, Alfons (author)
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Schmutzler, Rita K. (author)
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Sutter, Christian (author)
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Yang, Rongxi (author)
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Schuermann, Peter (author)
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Bremer, Michael (author)
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Christiansen, Hans (author)
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Park-Simon, Tjoung-Won (author)
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Hillemanns, Peter (author)
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Guenel, Pascal (author)
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Truong, Therese (author)
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Menegaux, Florence (author)
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Sanchez, Marie (author)
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Radice, Paolo (author)
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- Peterlongo, Paolo (author)
- Karolinska Institutet
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Manoukian, Siranoush (author)
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Pensotti, Valeria (author)
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Hopper, John L. (author)
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Tsimiklis, Helen (author)
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Apicella, Carmel (author)
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Southey, Melissa C. (author)
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Brauch, Hiltrud (author)
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Bruening, Thomas (author)
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Ko, Yon-Dschun (author)
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Sigurdson, Alice J. (author)
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Doody, Michele M. (author)
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Hamann, Ute (author)
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Torres, Diana (author)
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Ulmer, Hans-Ulrich (author)
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- Försti, Asta (author)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups
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Sawyer, Elinor J. (author)
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Tomlinson, Ian (author)
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Kerin, Michael J. (author)
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Miller, Nicola (author)
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Andrulis, Irene L. (author)
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Knight, Julia A. (author)
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Glendon, Gord (author)
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Mulligan, Anna Marie (author)
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Chenevix-Trench, Georgia (author)
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Balleine, Rosemary (author)
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Giles, Graham G. (author)
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Milne, Roger L. (author)
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McLean, Catriona (author)
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Lindblom, Annika (author)
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Margolin, Sara (author)
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Haiman, Christopher A. (author)
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Henderson, Brian E. (author)
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Schumacher, Fredrick (author)
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Le Marchand, Loic (author)
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Eilber, Ursula (author)
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Wang-Gohrke, Shan (author)
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Hooning, Maartje J. (author)
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Hollestelle, Antoinette (author)
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van den Ouweland, Ans M. W. (author)
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Koppert, Linetta B. (author)
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Carpenter, Jane (author)
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Clarke, Christine (author)
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Scott, Rodney (author)
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Mannermaa, Arto (author)
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Kataja, Vesa (author)
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Kosma, Veli-Matti (author)
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Hartikainen, Jaana M. (author)
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Brenner, Hermann (author)
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Arndt, Volker (author)
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Stegmaier, Christa (author)
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Dieffenbach, Aida Karina (author)
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Winqvist, Robert (author)
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Pylkaes, Katri (author)
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Jukkola-Vuorinen, Arja (author)
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Grip, Mervi (author)
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Offit, Kenneth (author)
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Vijai, Joseph (author)
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Robson, Mark (author)
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Rau-Murthy, Rohini (author)
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Dwek, Miriam (author)
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Swann, Ruth (author)
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Perkins, Katherine Annie (author)
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Goldberg, Mark S. (author)
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Labreche, France (author)
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Dumont, Martine (author)
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Eccles, Diana M. (author)
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Tapper, William J. (author)
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Rafiq, Sajjad (author)
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John, Esther M. (author)
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Whittemore, Alice S. (author)
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Slager, Susan (author)
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Yannoukakos, Drakoulis (author)
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Toland, Amanda E. (author)
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Yao, Song (author)
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Zheng, Wei (author)
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Halverson, Sandra L. (author)
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Gonzalez-Neira, Anna (author)
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Pita, Guillermo (author)
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Alonso, M. Rosario (author)
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Alvarez, Nuria (author)
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Herrero, Daniel (author)
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Tessier, Daniel C. (author)
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Vincent, Daniel (author)
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Bacot, Francois (author)
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Luccarini, Craig (author)
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Baynes, Caroline (author)
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Ahmed, Shahana (author)
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Maranian, Mel (author)
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Healey, Catherine S. (author)
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Simard, Jacques (author)
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Hall, Per (author)
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Easton, Douglas F. (author)
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Garcia-Closas, Montserrat (author)
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(creator_code:org_t)
- 2015-04-02
- 2015
- English.
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In: Journal of the National Cancer Institute. - : Oxford University Press (OUP). - 1460-2105 .- 0027-8874. ; 107:5, s. 036-036
- Related links:
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http://dx.doi.org/10... (free)
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https://academic.oup...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- Background: Data for multiple common susceptibility alleles for breast cancer may be combined to identify women at different levels of breast cancer risk. Such stratification could guide preventive and screening strategies. However, empirical evidence for genetic risk stratification is lacking. Methods: We investigated the value of using 77 breast cancer-associated single nucleotide polymorphisms (SNPs) for risk stratification, in a study of 33 673 breast cancer cases and 33 381 control women of European origin. We tested all possible pair-wise multiplicative interactions and constructed a 77-SNP polygenic risk score (PRS) for breast cancer overall and by estrogen receptor (ER) status. Absolute risks of breast cancer by PRS were derived from relative risk estimates and UK incidence and mortality rates. Results: There was no strong evidence for departure from a multiplicative model for any SNP pair. Women in the highest 1% of the PRS had a three-fold increased risk of developing breast cancer compared with women in the middle quintile (odds ratio [OR] = 3.36, 95% confidence interval [CI] = 2.95 to 3.83). The ORs for ER-positive and ER-negative disease were 3.73 (95% CI = 3.24 to 4.30) and 2.80 (95% CI = 2.26 to 3.46), respectively. Lifetime risk of breast cancer for women in the lowest and highest quintiles of the PRS were 5.2% and 16.6% for a woman without family history, and 8.6% and 24.4% for a woman with a first-degree family history of breast cancer. Conclusions: The PRS stratifies breast cancer risk in women both with and without a family history of breast cancer. The observed level of risk discrimination could inform targeted screening and prevention strategies. Further discrimination may be achievable through combining the PRS with lifestyle/environmental factors, although these were not considered in this report.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Mavaddat, Nasim
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Pharoah, Paul D. ...
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Michailidou, Kyr ...
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Tyrer, Jonathan
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Brook, Mark N.
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Bolla, Manjeet K ...
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show more...
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Wang, Qin
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Dennis, Joe
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Dunning, Alison ...
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Shah, Mitul
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Luben, Robert
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Brown, Judith
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Bojesen, Stig E.
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Nordestgaard, Bo ...
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Nielsen, Sune F.
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Flyger, Henrik
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Czene, Kamila
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Darabi, Hatef
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Eriksson, Mikael
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Peto, Julian
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dos-Santos-Silva ...
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Dudbridge, Frank
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Johnson, Nichola
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Schmidt, Marjank ...
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Broeks, Annegien
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Verhoef, Senno
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Rutgers, Emiel J ...
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Swerdlow, Anthon ...
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Ashworth, Alan
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Orr, Nick
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Schoemaker, Mino ...
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Figueroa, Jonine
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Chanock, Stephen ...
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Brinton, Louise
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Lissowska, Jolan ...
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Couch, Fergus J.
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Olson, Janet E.
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Vachon, Celine
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Pankratz, Vernon ...
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Lambrechts, Diet ...
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Wildiers, Hans
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Van Ongeval, Cha ...
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Van Limbergen, E ...
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Kristensen, Vess ...
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Alnaes, Grethe G ...
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Nord, Silje
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Borresen-Dale, A ...
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Nevanlinna, Heli
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Muranen, Taru A.
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Aittomaeki, Kris ...
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Blomqvist, Carl
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Chang-Claude, Je ...
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Rudolph, Anja
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Seibold, Petra
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Flesch-Janys, Di ...
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Fasching, Peter ...
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Haeberle, Lothar
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Ekici, Arif B.
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Beckmann, Matthi ...
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Burwinkel, Barba ...
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Marme, Frederik
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Schneeweiss, And ...
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Sohn, Christof
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Trentham-Dietz, ...
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Newcomb, Polly
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Titus, Linda
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Egan, Kathleen M ...
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Hunter, David J.
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Lindstrom, Sara
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Tamimi, Rulla M.
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Kraft, Peter
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Rahman, Nazneen
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Turnbull, Clare
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Renwick, Anthony
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Seal, Sheila
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Li, Jingmei
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Liu, Jianjun
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Humphreys, Keith
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Benitez, Javier
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Zamora, M. Pilar
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Perez, Jose Igna ...
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Menendez, Primit ...
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Jakubowska, Anna
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Lubinski, Jan
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Jaworska-Bieniek ...
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Durda, Katarzyna
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Bogdanova, Natal ...
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Antonenkova, Nat ...
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Doerk, Thilo
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Anton-Culver, Ho ...
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Neuhausen, Susan ...
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Ziogas, Argyrios
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Bernstein, Lesli ...
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Devilee, Peter
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Tollenaar, Rober ...
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Seynaeve, Caroli ...
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van Asperen, Chr ...
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Cox, Angela
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Cross, Simon S.
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Reed, Malcolm W. ...
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Khusnutdinova, E ...
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Bermisheva, Mari ...
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Prokofyeva, Dary ...
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Takhirova, Zalin ...
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Meindl, Alfons
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Schmutzler, Rita ...
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Sutter, Christia ...
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Yang, Rongxi
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Schuermann, Pete ...
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Bremer, Michael
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Christiansen, Ha ...
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Park-Simon, Tjou ...
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Hillemanns, Pete ...
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Guenel, Pascal
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Truong, Therese
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Menegaux, Floren ...
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Sanchez, Marie
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Radice, Paolo
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Peterlongo, Paol ...
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Manoukian, Siran ...
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Pensotti, Valeri ...
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Hopper, John L.
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Tsimiklis, Helen
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Apicella, Carmel
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Southey, Melissa ...
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Brauch, Hiltrud
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Bruening, Thomas
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Ko, Yon-Dschun
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Sigurdson, Alice ...
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Doody, Michele M ...
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Hamann, Ute
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Torres, Diana
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Ulmer, Hans-Ulri ...
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Försti, Asta
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Sawyer, Elinor J ...
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Tomlinson, Ian
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Kerin, Michael J ...
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Miller, Nicola
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Andrulis, Irene ...
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Knight, Julia A.
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Glendon, Gord
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Mulligan, Anna M ...
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Chenevix-Trench, ...
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Balleine, Rosema ...
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Giles, Graham G.
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Milne, Roger L.
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McLean, Catriona
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Lindblom, Annika
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Margolin, Sara
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Haiman, Christop ...
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Henderson, Brian ...
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Schumacher, Fred ...
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Le Marchand, Loi ...
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Eilber, Ursula
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Wang-Gohrke, Sha ...
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Hooning, Maartje ...
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Hollestelle, Ant ...
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van den Ouweland ...
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Koppert, Linetta ...
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Carpenter, Jane
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Clarke, Christin ...
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Scott, Rodney
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Mannermaa, Arto
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Kataja, Vesa
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Kosma, Veli-Matt ...
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Hartikainen, Jaa ...
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Brenner, Hermann
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Arndt, Volker
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Stegmaier, Chris ...
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Dieffenbach, Aid ...
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Winqvist, Robert
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Pylkaes, Katri
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Jukkola-Vuorinen ...
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Grip, Mervi
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Offit, Kenneth
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Vijai, Joseph
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Robson, Mark
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Rau-Murthy, Rohi ...
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Dwek, Miriam
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Swann, Ruth
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Perkins, Katheri ...
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Goldberg, Mark S ...
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Labreche, France
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Dumont, Martine
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Eccles, Diana M.
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Tapper, William ...
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Rafiq, Sajjad
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John, Esther M.
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Whittemore, Alic ...
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Slager, Susan
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Yannoukakos, Dra ...
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Toland, Amanda E ...
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Yao, Song
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Zheng, Wei
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Halverson, Sandr ...
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Gonzalez-Neira, ...
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Pita, Guillermo
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Alonso, M. Rosar ...
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Alvarez, Nuria
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Herrero, Daniel
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Tessier, Daniel ...
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Vincent, Daniel
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Bacot, Francois
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Luccarini, Craig
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Baynes, Caroline
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Ahmed, Shahana
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Maranian, Mel
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Healey, Catherin ...
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Simard, Jacques
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Hall, Per
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Easton, Douglas ...
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Garcia-Closas, M ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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Journal of the N ...
- By the university
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Lund University
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Karolinska Institutet