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  • Jost, Stefanie T.University Hospital of Cologne (author)

Levodopa Dose Equivalency in Parkinson's Disease : Updated Systematic Review and Proposals

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • 2023

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  • LIBRIS-ID:oai:lup.lub.lu.se:c5047c00-5e31-4fb5-aefc-713943c34cf3
  • https://lup.lub.lu.se/record/c5047c00-5e31-4fb5-aefc-713943c34cf3URI
  • https://doi.org/10.1002/mds.29410DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Background: To compare drug regimens across clinical trials in Parkinson's disease (PD) conversion formulae between antiparkinsonian drugs have been developed. These are reported in relation to levodopa as the benchmark drug in PD pharmacotherapy as ‘levodopa equivalent dose’ (LED). Currently, the LED conversion formulae proposed in 2010 by Tomlinson et al. based on a systematic review are predominantly used. However, new drugs with established and novel mechanisms of action and novel formulations of longstanding drugs have been developed since 2010. Therefore, consensus proposals for updated LED conversion formulae are needed. Objectives: To update LED conversion formulae based on a systematic review. Methods: The MEDLINE, CENTRAL, and Embase databases were searched from January 2010 to July 2021. Additionally, in a standardized process according to the GRADE grid method, consensus proposals were issued for drugs with scarce data on levodopa dose equivalency. Results: The systematic database search yielded 3076 articles of which 682 were eligible for inclusion in the systematic review. Based on these data and the standardized consensus process, we present proposals for LED conversion formulae for a wide range of drugs that are currently available for the pharmacotherapy of PD or are expected to be introduced soon. Conclusions: The LED conversion formulae issued in this Position Paper will serve as a research tool to compare the equivalence of antiparkinsonian medication across PD study cohorts and facilitate research on the clinical efficacy of pharmacological and surgical treatments as well as other non-pharmacological interventions in PD.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Kaldenbach, Marie AnnUniversity Hospital of Cologne (author)
  • Antonini, AngeloUniversity of Padova (author)
  • Martinez-Martin, PabloCIBER Enfermedades Neurodegenerativas (CIBERNED) (author)
  • Timmermann, LarsUniversity Hospital Giessen and Marburg (author)
  • Odin, PerLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Restorative Parkinson Unit,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Skåne University Hospital(Swepub:lu)med-poi (author)
  • Katzenschlager, Regina (author)
  • Borgohain, Rupam (author)
  • Fasano, AlfonsoUniversity of Toronto,Toronto Western Hospital (author)
  • Stocchi, FabrizioIRCCS San Raffaele Pisana (author)
  • Hattori, Nobutaka (author)
  • Kukkle, Prashanth LingappaManipal Hospital (author)
  • Rodríguez-Violante, MayelaInstituto Nacional de Neurología y Neurocirugía (author)
  • Falup-Pecurariu, CristianTransylvania University Brasov (author)
  • Schade, SebastianUniversity Medical Center Göttingen (author)
  • Petry-Schmelzer, Jan NiklasUniversity Hospital of Cologne (author)
  • Metta, VinodKing's College Hospital,King's College London (author)
  • Weintraub, DanielVeterans Health Administration,University of Pennsylvania (author)
  • Deuschl, GuentherUniversity Medical Center Schleswig-Holstein (author)
  • Espay, Alberto J.University of Cincinnati (author)
  • Tan, Eng KingSingapore General Hospital,Duke–NUS Medical School (author)
  • Bhidayasiri, Roongroj (author)
  • Fung, Victor S.C.Westmead Hospital (author)
  • Cardoso, FranciscoFederal University of Minas Gerais (author)
  • Trenkwalder, ClaudiaParacelsus-Elena-Klinik Kassel,University Medical Center Göttingen (author)
  • Jenner, PeterKing's College London (author)
  • Ray Chaudhuri, K.University Medical Center Göttingen,South London and Maudsley NHS Foundation Trust (author)
  • Dafsari, Haidar S.University Hospital of Cologne (author)
  • University Hospital of CologneUniversity of Padova (creator_code:org_t)
  • The International Parkinson and Movement Disorder Society Non Motor Parkinson's Disease Study Group

Related titles

  • In:Movement Disorders38:7, s. 1236-12520885-3185

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