onr:"swepub:oai:lup.lub.lu.se:c554bdf1-82f3-4f8f-bd29-0e1b5d4ac9bc"
Search: onr:"swepub:oai:lup.lub.lu.se:c554bdf1-82f3-4f8f-bd29-0e1b5d4ac9bc" > The use of a recomb...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Englund, UlricaLund University,Lunds universitet,Wallenberg Neurocentrum, Lund,Medicinska fakulteten,Wallenberg Neuroscience Centre, Lund,Faculty of Medicine,Lund University, Sweden (author)
The use of a recombinant lentiviral vector for ex vivo gene transfer into the rat CNS
- Article/chapterEnglish2000
Publisher, publication year, extent ...
- Lippincott Williams & Wilkins,2000
- 5 s.
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:c554bdf1-82f3-4f8f-bd29-0e1b5d4ac9bc
- https://lup.lub.lu.se/record/c554bdf1-82f3-4f8f-bd29-0e1b5d4ac9bcURI
- https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-120734URI
- https://doi.org/10.1097/00001756-200012180-00014DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- A major obstacle in ex vivo gene transfer has been the loss of transgene expression soon after implantation of the grafted transduced cells. Recently, a lentiviral vector system has been developed which has proven to express high levels of transgenes in vivo after direct injection into the tissue. In this study, we have investigated the use of such a vector for ex vivo gene transfer to the brain. A number of neural cell types were found to be permissive to transduction by the lentiviral vector in vitro and a majority of them expressed the transgene after transplantation to the rat brain. Transgene expression was detected up to 8 weeks post-grafting. These findings suggest that recombinant lentiviral vectors may be used for further development of ex vivo gene therapy protocols to the CNS.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
- Ex vivo gene transfer
- Green fluorescent protein
- Lentiviral vector
- Biomedical Sciences
Added entries (persons, corporate bodies, meetings, titles ...)
- Ericson, CeciliaLund University,Lunds universitet,Wallenberg Neurocentrum, Lund,Medicinska fakulteten,Wallenberg Neuroscience Centre, Lund,Faculty of Medicine,Lund University, Sweden(Swepub:lu)mphy-cen (author)
- Rosenblad, CarlNsGene A/S, Denmark(Swepub:lu)med-crd (author)
- Mandel, Ronald J.University of Florida College of Medicine, USA (author)
- Trono, DidierUniversity of Geneva Medical School, Switzerland (author)
- Wictorin, KlasLund University,Lunds universitet,Wallenberg Neurocentrum, Lund,Medicinska fakulteten,Wallenberg Neuroscience Centre, Lund,Faculty of Medicine,Lund University, Sweden(Swepub:lu)mphy-kwi (author)
- Lundberg, CeciliaLund University,Lunds universitet,Wallenberg Neurocentrum, Lund,Medicinska fakulteten,Wallenberg Neuroscience Centre, Lund,Faculty of Medicine,Lund University, Sweden(Swepub:lu)mphy-clu (author)
- Wallenberg Neurocentrum, LundMedicinska fakulteten (creator_code:org_t)
Related titles
- In:NeuroReport: Lippincott Williams & Wilkins11:18, s. 3973-39770959-49651473-558X
Internet link
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Englund, Ulrica
- Ericson, Cecilia
- Rosenblad, Carl
- Mandel, Ronald J ...
- Trono, Didier
- Wictorin, Klas
- show more...
- Lundberg, Cecili ...
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Neurosciences
- Articles in the publication
- NeuroReport
- By the university
- Lund University
- Linnaeus University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
