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HLA-DPB1*04:01 Protects Genetically Susceptible Children from Celiac Disease Autoimmunity in the TEDDY Study.
- Hadley, David (author)
- Hagopian, William (author)
- Liu, Edwin (author)
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- She, Jin-Xiong (author)
- Simell, Olli (author)
- Akolkar, Beena (author)
- Ziegler, Anette-G (author)
- Rewers, Marian (author)
- Krischer, Jeffrey P (author)
- Chen, Wei-Min (author)
- Onengut-Gumuscu, Suna (author)
- Bugawan, Teodorica L (author)
- Rich, Stephen S (author)
- Erlich, Henry (author)
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- (creator_code:org_t)
- Ovid Technologies (Wolters Kluwer Health), 2015
- 2015
- English.
- In: American Journal of Gastroenterology. - : Ovid Technologies (Wolters Kluwer Health). - 1572-0241 .- 0002-9270. ; 110:6, s. 915-920
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Tissue transglutaminase autoantibodies (tTGAs) represent the first evidence of celiac disease (CD) development. Associations of HLA-DR3-DQA1*05:01-DQB1*02:01 (i.e., DR3-DQ2) and, to a lesser extent, DR4-DQA1*03:01-DQB1*03:02 (i.e., DR4-DQ8) with the risk of CD differ by country, consistent with additional genetic heterogeneity that further refines risk. Therefore, we examined human leukocyte antigen (HLA) factors other than DR3-DQ2 for their contribution to developing tTGAs.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
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- ref (subject category)
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- Liu, Edwin
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- Simell, Olli
- Akolkar, Beena
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- Ziegler, Anette- ...
- Rewers, Marian
- Krischer, Jeffre ...
- Chen, Wei-Min
- Onengut-Gumuscu, ...
- Bugawan, Teodori ...
- Rich, Stephen S
- Erlich, Henry
- Agardh, Daniel
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- Lund University
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