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  • Marti, A.University of Navarra,Health Research Institute of Navarra (IDISNA),Carlos III Health Institute (author)

Serum and gene expression levels of CT-1, IL-6, and TNF-α after a lifestyle intervention in obese children

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2017-07-27
  • Hindawi Limited,2018
  • 6 s.

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  • LIBRIS-ID:oai:lup.lub.lu.se:c5a8087b-a09a-4d41-9bf3-1af5df7bf029
  • https://lup.lub.lu.se/record/c5a8087b-a09a-4d41-9bf3-1af5df7bf029URI
  • https://doi.org/10.1111/pedi.12561DOI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

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  • Background: Inflammation related molecules such as tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6), and cardiotrophin-1 (CT-1) are highly expressed in obese individuals and could partly explain some comorbidities associated to obesity. In obese children, lifestyle interventions are able to lower inflammation and reduce cardiovascular risk factors associated with obesity. The aim of the present work was to study changes in inflammation-related molecules serum and peripheral blood mononuclear cells (PBMC) transcript levels after a 10-week lifestyle intervention in obese children and asses their potential association with glucose metabolism. Methods: Twenty-three obese children (mean age 11.5 years; 48% males) underwent a 10-week lifestyle not controlled intervention trial. Anthropometric and biochemical measurements were analyzed. Transcript analysis for CT-1, IL-6, and TNF-α in PBMC were performed by RT-PCR. Serum cytokine levels were also measured at baseline and after 10-weeks. Results: Participants achieved a significant reduction in body adiposity (0.34 decrease in body mass index-standard deviation), total cholesterol, and glucose levels after 10-weeks. A Significant decrease in serum TNF-α and C reactive protein (CRP) were observed. CT-1 transcript levels were significantly reduced (P =.005) after lifestyle intervention, and these changes were significantly correlated with changes in serum CT-1 levels (r = 0.451; P =.031). In multiple regression analysis baseline CT-1 transcript levels were positively associated with final insulin (R2 = 0.506; P =.035) and HOMA-IR values (R2 = 0.473; P =.034). Conclusions: We reported that serum CRP, TNF-α, as well as PBMC CT-1 transcript levels were reduced after lifestyle intervention in obese children. More studies are needed to clarify the role of inflammation-related molecules in glucose metabolism.

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  • Morell-Azanza, L.Health Research Institute of Navarra (IDISNA),University of Navarra (author)
  • Rendo-Urteaga, T.University of São Paulo (author)
  • García-Calzón, S.Lund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups,Health Research Institute of Navarra (IDISNA)(Swepub:lu)med-sg_ (author)
  • Ojeda-Rodríguez, A.Health Research Institute of Navarra (IDISNA),University of Navarra (author)
  • Martín-Calvo, N.Carlos III Health Institute,University of Navarra,Health Research Institute of Navarra (IDISNA) (author)
  • Moreno-Aliaga, M. J.Carlos III Health Institute,Health Research Institute of Navarra (IDISNA),University of Navarra (author)
  • Martínez, J. A.IMDEA Institute,Carlos III Health Institute,Health Research Institute of Navarra (IDISNA),University of Navarra (author)
  • Azcona-San Julián, M. C.University of Navarra,Health Research Institute of Navarra (IDISNA) (author)
  • University of NavarraHealth Research Institute of Navarra (IDISNA) (creator_code:org_t)

Related titles

  • In:Pediatric Diabetes: Hindawi Limited19:2, s. 217-2221399-543X

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