Search: onr:"swepub:oai:lup.lub.lu.se:c6ef0dc4-cc87-41d1-bbc2-a077c8f660ad" >
Enhancer hijacking ...
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Northcott, Paul A
(author)
Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma.
- Article/chapterEnglish2014
Publisher, publication year, extent ...
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2014-06-22
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Springer Science and Business Media LLC,2014
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:c6ef0dc4-cc87-41d1-bbc2-a077c8f660ad
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https://lup.lub.lu.se/record/4581678URI
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https://doi.org/10.1038/nature13379DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Medulloblastoma is a highly malignant paediatric brain tumour currently treated with a combination of surgery, radiation and chemotherapy, posing a considerable burden of toxicity to the developing child. Genomics has illuminated the extensive intertumoral heterogeneity of medulloblastoma, identifying four distinct molecular subgroups. Group 3 and group 4 subgroup medulloblastomas account for most paediatric cases; yet, oncogenic drivers for these subtypes remain largely unidentified. Here we describe a series of prevalent, highly disparate genomic structural variants, restricted to groups 3 and 4, resulting in specific and mutually exclusive activation of the growth factor independent 1 family proto-oncogenes, GFI1 and GFI1B. Somatic structural variants juxtapose GFI1 or GFI1B coding sequences proximal to active enhancer elements, including super-enhancers, instigating oncogenic activity. Our results, supported by evidence from mouse models, identify GFI1 and GFI1B as prominent medulloblastoma oncogenes and implicate 'enhancer hijacking' as an efficient mechanism driving oncogene activation in a childhood cancer.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Lee, Catherine
(author)
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Zichner, Thomas
(author)
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Stütz, Adrian M
(author)
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Erkek, Serap
(author)
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Kawauchi, Daisuke
(author)
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Shih, David J H
(author)
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Hovestadt, Volker
(author)
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Zapatka, Marc
(author)
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Sturm, Dominik
(author)
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Jones, David T W
(author)
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Kool, Marcel
(author)
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Remke, Marc
(author)
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Cavalli, Florence M G
(author)
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Zuyderduyn, Scott
(author)
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Bader, Gary D
(author)
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VandenBerg, Scott
(author)
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Esparza, Lourdes Adriana
(author)
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Ryzhova, Marina
(author)
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Wang, Wei
(author)
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Wittmann, Andrea
(author)
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Stark, Sebastian
(author)
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Sieber, Laura
(author)
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Seker-Cin, Huriye
(author)
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Linke, Linda
(author)
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Kratochwil, Fabian
(author)
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Jäger, Natalie
(author)
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Buchhalter, Ivo
(author)
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Imbusch, Charles D
(author)
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Zipprich, Gideon
(author)
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Raeder, Benjamin
(author)
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Schmidt, Sabine
(author)
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Diessl, Nicolle
(author)
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Wolf, Stephan
(author)
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Wiemann, Stefan
(author)
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Brors, Benedikt
(author)
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Lawerenz, Chris
(author)
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Eils, Jürgen
(author)
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Warnatz, Hans-Jörg
(author)
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Risch, Thomas
(author)
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Yaspo, Marie-Laure
(author)
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Weber, Ursula D
(author)
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Bartholomae, Cynthia C
(author)
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von Kalle, Christof
(author)
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Turányi, Eszter
(author)
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Hauser, Peter
(author)
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Sandén, EmmaLund University,Lunds universitet,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurosurgery,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-esd
(author)
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Darabi, AnnaLund University,Lunds universitet,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurosurgery,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)wbl-ajo
(author)
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Siesjö, PeterLund University,Lunds universitet,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurosurgery,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)nkir-psi
(author)
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Sterba, Jaroslav
(author)
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Zitterbart, Karel
(author)
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Sumerauer, David
(author)
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van Sluis, Peter
(author)
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Versteeg, Rogier
(author)
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Volckmann, Richard
(author)
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Koster, Jan
(author)
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Schuhmann, Martin U
(author)
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Ebinger, Martin
(author)
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Grimes, H Leighton
(author)
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Robinson, Giles W
(author)
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Gajjar, Amar
(author)
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Mynarek, Martin
(author)
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von Hoff, Katja
(author)
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Rutkowski, Stefan
(author)
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Pietsch, Torsten
(author)
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Scheurlen, Wolfram
(author)
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Felsberg, Jörg
(author)
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Reifenberger, Guido
(author)
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Kulozik, Andreas E
(author)
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von Deimling, Andreas
(author)
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Witt, Olaf
(author)
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Eils, Roland
(author)
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Gilbertson, Richard J
(author)
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Korshunov, Andrey
(author)
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Taylor, Michael D
(author)
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Lichter, Peter
(author)
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Korbel, Jan O
(author)
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Wechsler-Reya, Robert J
(author)
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Pfister, Stefan M
(author)
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NeurokirurgiSektion IV
(creator_code:org_t)
Related titles
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In:Nature: Springer Science and Business Media LLC511:7510, s. 428-4280028-08361476-4687
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To the university's database
- By the author/editor
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Northcott, Paul ...
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Lee, Catherine
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Zichner, Thomas
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Stütz, Adrian M
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Erkek, Serap
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Kawauchi, Daisuk ...
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show more...
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Shih, David J H
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Hovestadt, Volke ...
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Zapatka, Marc
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Sturm, Dominik
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Jones, David T W
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Kool, Marcel
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Remke, Marc
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Cavalli, Florenc ...
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Zuyderduyn, Scot ...
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Bader, Gary D
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VandenBerg, Scot ...
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Esparza, Lourdes ...
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Ryzhova, Marina
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Wang, Wei
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Wittmann, Andrea
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Stark, Sebastian
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Sieber, Laura
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Seker-Cin, Huriy ...
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Linke, Linda
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Kratochwil, Fabi ...
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Jäger, Natalie
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Buchhalter, Ivo
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Imbusch, Charles ...
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Zipprich, Gideon
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Raeder, Benjamin
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Schmidt, Sabine
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Diessl, Nicolle
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Wolf, Stephan
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Wiemann, Stefan
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Brors, Benedikt
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Lawerenz, Chris
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Eils, Jürgen
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Warnatz, Hans-Jö ...
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Risch, Thomas
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Yaspo, Marie-Lau ...
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Weber, Ursula D
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Bartholomae, Cyn ...
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von Kalle, Chris ...
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Turányi, Eszter
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Hauser, Peter
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Sandén, Emma
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Darabi, Anna
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Siesjö, Peter
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Sterba, Jaroslav
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Zitterbart, Kare ...
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Sumerauer, David
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van Sluis, Peter
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Versteeg, Rogier
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Volckmann, Richa ...
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Koster, Jan
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Schuhmann, Marti ...
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Ebinger, Martin
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Grimes, H Leight ...
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Robinson, Giles ...
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Gajjar, Amar
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Mynarek, Martin
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von Hoff, Katja
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Rutkowski, Stefa ...
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Pietsch, Torsten
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Scheurlen, Wolfr ...
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Felsberg, Jörg
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Reifenberger, Gu ...
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Kulozik, Andreas ...
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von Deimling, An ...
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Witt, Olaf
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Eils, Roland
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Gilbertson, Rich ...
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Korshunov, Andre ...
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Taylor, Michael ...
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Lichter, Peter
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Korbel, Jan O
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Wechsler-Reya, R ...
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Pfister, Stefan ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Neurology
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Nature
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Lund University