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Important research ...
Important research questions in allergy and related diseases: 3-chronic rhinosinusitis and nasal polyposis - a GA(2)LEN study
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Bachert, C. (author)
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Van Bruaene, N. (author)
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Toskala, E. (author)
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Zhang, N. (author)
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Olze, H. (author)
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Scadding, G. (author)
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Van Drunen, C. M. (author)
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Mullol, J. (author)
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- Cardell, L. (author)
- Karolinska Institutet
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Gevaert, P. (author)
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Van Zele, T. (author)
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Claeys, S. (author)
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- Halldén, Christer (author)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups
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Kostamo, K. (author)
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Foerster, U. (author)
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Kowalski, M. (author)
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Bieniek, K. (author)
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Olszewska-Ziaber, A. (author)
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Nizankowska-Mogilnicka, E. (author)
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Szczeklik, A. (author)
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Swierczynska, M. (author)
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Arcimowicz, M. (author)
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Lund, V. (author)
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Fokkens, W. (author)
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Zuberbier, T. (author)
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Akdis, C. (author)
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Canonica, G. (author)
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Van Cauwenberge, P. (author)
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Burney, P. (author)
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Bousquet, J. (author)
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(creator_code:org_t)
- Wiley, 2009
- 2009
- English.
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In: Allergy. - : Wiley. - 1398-9995 .- 0105-4538. ; 64:4, s. 520-533
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Abstract
Subject headings
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- Chronic rhinosinusitis is one of the most common health care challenges, with significant direct medical costs and severe impact on lower airway disease and general health outcomes. The diagnosis of chronic rhinosinusitis (CRS) currently is based on clinical signs, nasal endoscopy and CT scanning, and therapeutic recommendations are focussing on 2 classes of drugs, corticosteroids and antibiotics. A better understanding of the pathogenesis and the factors amplifying mucosal inflammation therefore seems to be crucial for the development of new diagnostic and therapeutic tools. In an effort to extend knowledge in this area, the WP 2.7.2 of the GA(2)LEN network of excellence currently collects data and samples of 1000 CRS patients and 250 control subjects. The main objective of this project is to characterize patients with upper airway disease on the basis of clinical parameters, infectious agents, inflammatory mechanisms and remodeling processes. This collaborative research will result in better knowledge on patient phenotypes, pathomechanisms, and subtypes in chronic rhinosinusitis. This review summarizes the state of the art on chronic rhinosinusitis and nasal polyposis in different aspects of the disease. It defines potential gaps in the current research, and points to future research perspectives and targets.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- superantigens
- nasal polyposis
- inflammation
- biomarkers
- chronic rhinosinusitis
- T-cells
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Allergy
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To the university's database
- By the author/editor
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Bachert, C.
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Van Bruaene, N.
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Toskala, E.
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Zhang, N.
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Olze, H.
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Scadding, G.
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show more...
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Van Drunen, C. M ...
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Mullol, J.
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Cardell, L.
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Gevaert, P.
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Van Zele, T.
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Claeys, S.
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Halldén, Christe ...
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Kostamo, K.
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Foerster, U.
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Kowalski, M.
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Bieniek, K.
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Olszewska-Ziaber ...
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Nizankowska-Mogi ...
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Szczeklik, A.
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Swierczynska, M.
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Arcimowicz, M.
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Lund, V.
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Fokkens, W.
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Zuberbier, T.
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Akdis, C.
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Canonica, G.
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Van Cauwenberge, ...
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Burney, P.
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Bousquet, J.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
- Articles in the publication
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Allergy
- By the university
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Lund University
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Karolinska Institutet