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  • Chivasso, ClaraUniversité Libre de Bruxelles (ULB) (author)

Unraveling human aqp5-pip molecular interaction and effect on aqp5 salivary glands localization in ss patients

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-08-17
  • MDPI AG,2021

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:c757bbca-50a0-4624-b1c4-6392fbf44368
  • https://lup.lub.lu.se/record/c757bbca-50a0-4624-b1c4-6392fbf44368URI
  • https://doi.org/10.3390/cells10082108DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Saliva secretion requires effective translocation of aquaporin 5 (AQP5) water channel to the salivary glands (SGs) acinar apical membrane. Patients with Sjögren’s syndrome (SS) display abnormal AQP5 localization within acinar cells from SGs that correlate with sicca manifestation and glands hypofunction. Several proteins such as Prolactin-inducible protein (PIP) may regulate AQP5 trafficking as observed in lacrimal glands from mice. However, the role of the AQP5-PIP complex remains poorly understood. In the present study, we show that PIP interacts with AQP5 in vitro and in mice as well as in human SGs and that PIP misexpression correlates with an altered AQP5 distribution at the acinar apical membrane in PIP knockout mice and SS hMSG. Furthermore, our data show that the protein-protein interaction involves the AQP5 C-terminus and the N-terminal of PIP (one molecule of PIP per AQP5 tetramer). In conclusion, our findings highlight for the first time the role of PIP as a protein controlling AQP5 localization in human salivary glands but extend beyond due to the PIP-AQP5 interaction described in lung and breast cancers.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Nesverova, VeronikaLund University,Lunds universitet,Biokemi och Strukturbiologi,Centrum för Molekylär Proteinvetenskap,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biochemistry and Structural Biology,Center for Molecular Protein Science,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)bioc-ven (author)
  • Järvå, MichaelUniversity of Gothenburg (author)
  • Blanchard, AnneUniversity of Manitoba (author)
  • Rose, Kristie L.Vanderbilt University (author)
  • Öberg, Fredrik KryhUniversity of Gothenburg (author)
  • Wang, ZhenVanderbilt University (author)
  • Martin, MaudUniversité Libre de Bruxelles (ULB) (author)
  • Lhotellerie, FlorentUniversité Libre de Bruxelles (ULB) (author)
  • Zindy, EgorCenter for Microscopy and Molecular Imaging (author)
  • Junqueira, BrunaCatholic University of Louvain (author)
  • Leroy, KarelleUniversité Libre de Bruxelles (ULB) (author)
  • Vanhollebeke, BenoitUniversité Libre de Bruxelles (ULB) (author)
  • Delforge, ValérieUniversité Libre de Bruxelles (ULB) (author)
  • Bolaky, NargisUniversité Libre de Bruxelles (ULB) (author)
  • Perret, JasonUniversité Libre de Bruxelles (ULB) (author)
  • Soyfoo, Muhammad ShahnawazUniversité Libre de Bruxelles (ULB) (author)
  • Moscato, StefaniaUniversity of Pisa (author)
  • Baldini, ChiaraUniversity of Pisa (author)
  • Chaumont, FrançoisCatholic University of Louvain (author)
  • Mattii, LetiziaUniversity of Pisa (author)
  • Schey, Kevin L.Vanderbilt University (author)
  • Myal, YvonneUniversity of Manitoba (author)
  • Törnroth-Horsefield, SusannaLund University,Lunds universitet,Biokemi och Strukturbiologi,Centrum för Molekylär Proteinvetenskap,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biochemistry and Structural Biology,Center for Molecular Protein Science,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)bioc-sst (author)
  • Delporte, ChristineUniversité Libre de Bruxelles (ULB) (author)
  • Université Libre de Bruxelles (ULB)Biokemi och Strukturbiologi (creator_code:org_t)

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  • In:Cells: MDPI AG10:82073-4409

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