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Integrative analysi...
Integrative analysis for finding genes and networks involved in diabetes and other complex diseases
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Bergholdt, Regine (author)
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Storling, Zenia M. (author)
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Lage, Kasper (author)
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Karlberg, E. Olof (author)
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Olason, Pall I. (author)
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Aalund, Mogens (author)
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- Nerup, Jörn (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine
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Brunak, Soren (author)
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Workman, Christopher T. (author)
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- Pociot, Flemming (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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(creator_code:org_t)
- Springer Science and Business Media LLC, 2007
- 2007
- English.
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In: Genome Biology. - : Springer Science and Business Media LLC. - 1474-7596 .- 1465-6906. ; 8:11
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http://dx.doi.org/10... (free)
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https://genomebiolog...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- We have developed an integrative analysis method combining genetic interactions, identified using type l diabetes genome scan data, and a high-confidence human protein interaction network. Resulting networks were ranked by the significance of the enrichment of proteins from interacting regions. We identified a number of new protein network modules and novel candidate genes/ proteins for type 1 diabetes. We propose this type of integrative analysis as a general method for the elucidation of genes and networks involved in diabetes and other complex diseases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Bergholdt, Regin ...
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Storling, Zenia ...
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Lage, Kasper
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Karlberg, E. Olo ...
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Olason, Pall I.
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Aalund, Mogens
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show more...
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Nerup, Jörn
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Brunak, Soren
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Workman, Christo ...
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Pociot, Flemming
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Other Clinical M ...
- Articles in the publication
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Genome Biology
- By the university
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Lund University