Aerobic fitness, muscular strength and obesity in relation to risk of heart failure

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Crump, CaseyIcahn School of Medicine at Mount Sinai (author)

Aerobic fitness, muscular strength and obesity in relation to risk of heart failure

Article/chapterEnglish2017

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2017-05-12
BMJ,2017
8 s.

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LIBRIS-ID:oai:lup.lub.lu.se:c85b2e2d-c669-4a70-a942-18c4f4941af1
https://lup.lub.lu.se/record/c85b2e2d-c669-4a70-a942-18c4f4941af1URI
https://doi.org/10.1136/heartjnl-2016-310716DOI

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Language:English
Summary in:English

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Objective Low physical fitness and obesity have been associated with higher risk of developing heart failure (HF), but their interactive effects are unknown. Elucidation of interactions among these common modifiable factors may help facilitate more effective primary prevention. Methods We conducted a national cohort study to examine the interactive effects of aerobic fitness, muscular strength and body mass index (BMI) among 1 330 610 military conscripts in Sweden during 1969-1997 (97%-98% of all 18-year-old men) on risk of HF identified from inpatient and outpatient diagnoses through 2012 (maximum age 62 years). Results There were 11 711 men diagnosed with HF in 37.8 million person-years of follow-up. Low aerobic fitness, low muscular strength and obesity were independently associated with higher risk of HF, after adjusting for each other, socioeconomic factors, other chronic diseases and family history of HF. The combination of low aerobic fitness and low muscular strength (lowest vs highest tertiles) was associated with a 1.7-fold risk of HF (95% CI 1.6 to 1.9; p<0.001; incidence rates per 100 000 person-years, 43.2 vs 10.8). These factors had positive additive and multiplicative interactions (p<0.001) and were associated with increased risk of HF even among men with normal BMI. Conclusions Low aerobic fitness, low muscular strength and obesity at the age of 18 years were independently associated with higher risk of HF in adulthood, with interactive effects between aerobic fitness and muscular strength. These findings suggest that early-life interventions may help reduce the long-term risk of HF and should include both aerobic fitness and muscular strength, even among persons with normal BMI.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
body mass index
heart failure
muscle strength
obesity
physical fitness

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Sundquist, JanLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups(Swepub:lu)med-jsu (author)
Winkleby, Marilyn A.Stanford University(Swepub:lu)med-mwe (author)
Sundquist, KristinaLund University,Lunds universitet,Allmänmedicin, kardiovaskulär epidemiologi och levnadsvanor,Forskargrupper vid Lunds universitet,Family Medicine, Cardiovascular Epidemiology and Lifestyle,Lund University Research Groups(Swepub:lu)med-ksq (author)
Icahn School of Medicine at Mount SinaiAllmänmedicin och klinisk epidemiologi (creator_code:org_t)

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In:Heart: BMJ103:22, s. 1780-17871355-60371468-201X

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