Impact of pathogen reduction methods on immunological properties of the COVID-19 convalescent plasma

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Impact of pathogen reduction methods on immunological properties of the COVID-19 convalescent plasma

Kostin, Alexander I. (author): N.V. Sklifosovsky Research Institute of Emergency Medicine

Lundgren, Maria N. (author): Region Skåne

Bulanov, Andrey Y. (author): N.V. Sklifosovsky Research Institute of Emergency Medicine

Ladygina, Elena A. (author): N.V. Sklifosovsky Research Institute of Emergency Medicine

Chirkova, Karina S. (author): N.V. Sklifosovsky Research Institute of Emergency Medicine

Gintsburg, Alexander L. (author): Gamaleya Research Institute of Epidemiology and Microbiology

Logunov, Denis Y. (author): Gamaleya Research Institute of Epidemiology and Microbiology

Dolzhikova, Inna V. (author): Gamaleya Research Institute of Epidemiology and Microbiology

Shcheblyakov, Dmitry V. (author): Gamaleya Research Institute of Epidemiology and Microbiology

Borovkova, Natalia V. (author): N.V. Sklifosovsky Research Institute of Emergency Medicine

Godkov, Mikhail A. (author): N.V. Sklifosovsky Research Institute of Emergency Medicine

Bazhenov, Alexey I. (author): N.V. Sklifosovsky Research Institute of Emergency Medicine

Shustov, Valeriy V. (author): N.V. Sklifosovsky Research Institute of Emergency Medicine

Bogdanova, Alina S. (author): N.V. Sklifosovsky Research Institute of Emergency Medicine

Kamalova, Alina R. (author): Pirogov Russian National Research Medical University (RNRMU)

Ganchin, Vladimir V. (author): Centre of Social Sector Analytical Development, Moscow

Dombrovskiy, Eugene A. (author): Centre of Social Sector Analytical Development, Moscow

Volkov, Stanislav E. (author): Lund University,Lunds universitet,Probability and Inference Theory Group,Forskargrupper vid Lunds universitet,Matematisk statistik,Matematikcentrum,Institutioner vid LTH,Lunds Tekniska Högskola,Lund University Research Groups,Mathematical Statistics,Centre for Mathematical Sciences,Departments at LTH,Faculty of Engineering, LTH

Drozdova, Nataliya E. (author): N.V. Sklifosovsky Research Institute of Emergency Medicine

Petrikov, Sergey S. (author): N.V. Sklifosovsky Research Institute of Emergency Medicine

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NV. Sklifosovsky Research Institute of Emergency Medicine Region Skåne (creator_code:org_t)

2021-03-18
2021
English.
In: Vox Sanguinis. - : Wiley. - 0042-9007 .- 1423-0410. ; 116:6, s. 665-672

Related links:: http://dx.doi.org/10...; show more...; https://www.ncbi.nlm...; https://lup.lub.lu.s...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Background and objectives: COVID-19 convalescent plasma is an experimental treatment against SARS-CoV-2. The aim of this study is to assess the impact of different pathogen reduction methods on the levels and virus neutralizing activity of the specific antibodies against SARS-CoV2 in convalescent plasma. Materials and methods: A total of 140 plasma doses collected by plasmapheresis from COVID-19 convalescent donors were subjected to pathogen reduction by three methods: methylene blue (M)/visible light, riboflavin (R)/UVB and amotosalen (A)/UVA. To conduct a paired comparison, individual plasma doses were divided into 2 samples that were subjected to one of these methods. The titres of SARS-CoV2 neutralizing antibodies (NtAbs) and levels of specific immunoglobulins to RBD, S- and N-proteins of SARS-CoV-2 were measured before and after pathogen reduction. Results: The methods reduced NtAbs titres differently: among units with the initial titre 80 or above, 81% of units remained unchanged and 19% decreased by one step after methylene blue; 60% were unchanged and 40% decreased by one step after amotosalen; after riboflavin 43% were unchanged and 50% (7%, respectively) had a one-step (two-step, respectively) decrease. Paired two-sample comparisons (M vs. A, M vs. R and A vs. R) revealed that the largest statistically significant decrease in quantity and activity of the specific antibodies resulted from the riboflavin treatment. Conclusion: Pathogen reduction with methylene blue or with amotosalen provides the greater likelihood of preserving the immunological properties of the COVID-19 convalescent plasma compared to riboflavin.

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Infectious Medic ...

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Impact of pathogen reduction methods on immunological properties of the COVID-19 convalescent plasma

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