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- Hansson, ChristerLund University,Lunds universitet,Dermatologi och venereologi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Dermatology and Venereology (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine (author)
Stability of the mercaptobenzothiazole compounds
- Article/chapterEnglish1993
Publisher, publication year, extent ...
- 2006-04-11
- Wiley,1993
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:c987b4b7-ce3b-44b9-b2e1-5d094f8550b0
- https://lup.lub.lu.se/record/1107445URI
- https://doi.org/10.1111/j.1600-0536.1993.tb03320.xDOI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- An analytical quantitative high-pressure liquid chromatography (HPLC) method was developed for simultaneous determination of all mercaptobenzothiazole derivatives in the mercapto mix patch testing standard. The stability of the mercaptobenzothiazoles constituting the mercapto mix was studied both in petrolatum and in buffer solution at pH 6.5, with and without glutathione. In petrolatum vehicle, dibenzothiazyl disulfide was the dominant compound found in stored mercapto mix. In buffer solution at pH 6.5, 2-mercaptobenzothiazole and the sulfenamide derivatives morpholinyl mercaptobenzothiazole and N-cyclohexyl-2-benzothiazyl sulfenamide were converted into dibenzothiazyl disulfide. In the presence of glutathione, both the sulfenamide derivatives and the dibenzothiazyl disulfide were rapidly converted into 2-mercaptobenzothiazole. The findings explain the "cross-sensitivities" reported for the mercaptobenzothiazole group as a result of chemical reactions resulting in one main hapten. The use of a single substance for patch testing for mercaptobenzothiazole hypersensitivity is proposed.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Dermatologi och venereologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Dermatology and Venereal Diseases hsv//eng
- mercaptobenzothiazole
- rubber
- glutathione
- cross-sensitivity
- patch testing technique
- mercapto mix
- contact allergy
Added entries (persons, corporate bodies, meetings, titles ...)
- Agrup, GunLund University,Lunds universitet,Dermatologi och venereologi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Dermatology and Venereology (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)derm-gag (author)
- Dermatologi och venereologi, LundSektion III (creator_code:org_t)
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- In:Contact Dermatitis: Wiley28:1, s. 29-340105-1873
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