Search: onr:"swepub:oai:lup.lub.lu.se:cb69de7b-cbad-434d-8667-537a2aca4cf6" >
Time-resolved autoa...
Time-resolved autoantibody profiling facilitates stratification of preclinical type 1 diabetes in children
-
- Endesfelder, David (author)
- Helmholtz Zentrum München
-
- zu Castell, Wolfgang (author)
- Technical University of Munich,Helmholtz Zentrum München
-
- Bonifacio, Ezio (author)
- Dresden University of Technology,German Center for Diabetes Research
-
show more...
-
- Rewers, Marian (author)
- University of Colorado
-
- Hagopian, William A. (author)
- Pacific Northwest Research Institute
-
- She, Jin Xiong (author)
- Medical College of Georgia
-
- Lernmark, Ake (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital
-
- Toppari, Jorma (author)
- Turku University Hospital,University of Turku
-
- Vehik, Kendra (author)
- University of South Florida
-
- Williams, Alistair J.K. (author)
- Southmead Hospital,University of Bristol
-
- Yu, Liping (author)
- University of Colorado
-
- Akolkar, Beena (author)
- National Institute of Diabetes and Digestive and Kidney Diseases
-
- Krischer, Jeffrey P. (author)
- University of South Florida
-
- Ziegler, Anette G. (author)
- German Center for Diabetes Research,Klinikum rechts der Isar,Helmholtz Zentrum München
-
- Achenbach, Peter (author)
- Klinikum rechts der Isar,German Center for Diabetes Research,Helmholtz Zentrum München
-
show less...
-
(creator_code:org_t)
-
- 2018-10-10
- 2019
- English 12 s.
-
In: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 68:1, s. 119-130
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://diabetes.dia...
-
https://lup.lub.lu.s...
-
https://doi.org/10.2...
-
show less...
Abstract
Subject headings
Close
- Progression to clinical type 1 diabetes varies among children who develop b-cell autoantibodies. Differences in autoantibody patterns could relate to disease progression and etiology. Here we modeled complex longitudinal autoantibody profiles by using a novel wavelet-based algorithm. We identified clusters of similar profiles associated with various types of progression among 600 children from The Environmental Determinants of Diabetes in the Young (TEDDY) birth cohort study; these children developed persistent insulin autoantibodies (IAA), GAD autoantibodies (GADA), insulinoma-associated antigen 2 autoantibodies (IA-2A), or a combination of these, and they were followed up prospectively at 3- to 6-month intervals (median follow-up 6.5 years). Children who developed multiple autoantibody types (n = 370) were clustered, and progression from seroconversion to clinical diabetes within 5 years ranged between clusters from 6% (95% CI 0, 17.4) to 84% (59.2, 93.6). Children who seroconverted early in life (median age <2 years) and developed IAA and IA-2A that were stable-positive on follow-up had the highest risk of diabetes, and this risk was unaffected by GADA status. Clusters of children who lacked stable-positive GADA responses contained more boys and lower frequencies of the HLA-DR3 allele. Our novel algorithm allows refined grouping of b-cell autoantibody–positive children who distinctly progressed to clinical type 1 diabetes, and it provides new opportunities in searching for etiological factors and elucidating complex disease mechanisms.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
-
Diabetes
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Endesfelder, Dav ...
-
zu Castell, Wolf ...
-
Bonifacio, Ezio
-
Rewers, Marian
-
Hagopian, Willia ...
-
She, Jin Xiong
-
show more...
-
Lernmark, Ake
-
Toppari, Jorma
-
Vehik, Kendra
-
Williams, Alista ...
-
Yu, Liping
-
Akolkar, Beena
-
Krischer, Jeffre ...
-
Ziegler, Anette ...
-
Achenbach, Peter
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Endocrinology an ...
- Articles in the publication
-
Diabetes
- By the university
-
Lund University