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Time-resolved autoa...
Time-resolved autoantibody profiling facilitates stratification of preclinical type 1 diabetes in children
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- Endesfelder, David (author)
- Helmholtz Zentrum München
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- zu Castell, Wolfgang (author)
- Helmholtz Zentrum München,Technical University of Munich
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- Bonifacio, Ezio (author)
- German Center for Diabetes Research,Dresden University of Technology
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- Rewers, Marian (author)
- University of Colorado
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- Hagopian, William A. (author)
- Pacific Northwest Research Institute
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- She, Jin Xiong (author)
- Medical College of Georgia
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- Lernmark, Ake (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital
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- Toppari, Jorma (author)
- Turku University Hospital,University of Turku
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- Vehik, Kendra (author)
- University of South Florida
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- Williams, Alistair J.K. (author)
- University of Bristol,Southmead Hospital
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- Yu, Liping (author)
- University of Colorado
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- Akolkar, Beena (author)
- National Institute of Diabetes and Digestive and Kidney Diseases
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- Krischer, Jeffrey P. (author)
- University of South Florida
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- Ziegler, Anette G. (author)
- Klinikum rechts der Isar,Helmholtz Zentrum München,German Center for Diabetes Research
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- Achenbach, Peter (author)
- Helmholtz Zentrum München,German Center for Diabetes Research,Klinikum rechts der Isar
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(creator_code:org_t)
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- 2018-10-10
- 2019
- English 12 s.
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In: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 68:1, s. 119-130
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http://dx.doi.org/10...
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https://diabetes.dia...
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Abstract
Subject headings
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- Progression to clinical type 1 diabetes varies among children who develop b-cell autoantibodies. Differences in autoantibody patterns could relate to disease progression and etiology. Here we modeled complex longitudinal autoantibody profiles by using a novel wavelet-based algorithm. We identified clusters of similar profiles associated with various types of progression among 600 children from The Environmental Determinants of Diabetes in the Young (TEDDY) birth cohort study; these children developed persistent insulin autoantibodies (IAA), GAD autoantibodies (GADA), insulinoma-associated antigen 2 autoantibodies (IA-2A), or a combination of these, and they were followed up prospectively at 3- to 6-month intervals (median follow-up 6.5 years). Children who developed multiple autoantibody types (n = 370) were clustered, and progression from seroconversion to clinical diabetes within 5 years ranged between clusters from 6% (95% CI 0, 17.4) to 84% (59.2, 93.6). Children who seroconverted early in life (median age <2 years) and developed IAA and IA-2A that were stable-positive on follow-up had the highest risk of diabetes, and this risk was unaffected by GADA status. Clusters of children who lacked stable-positive GADA responses contained more boys and lower frequencies of the HLA-DR3 allele. Our novel algorithm allows refined grouping of b-cell autoantibody–positive children who distinctly progressed to clinical type 1 diabetes, and it provides new opportunities in searching for etiological factors and elucidating complex disease mechanisms.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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Diabetes
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- By the author/editor
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Endesfelder, Dav ...
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zu Castell, Wolf ...
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Bonifacio, Ezio
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Rewers, Marian
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Hagopian, Willia ...
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She, Jin Xiong
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show more...
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Lernmark, Ake
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Toppari, Jorma
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Vehik, Kendra
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Williams, Alista ...
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Yu, Liping
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Akolkar, Beena
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Krischer, Jeffre ...
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Ziegler, Anette ...
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Achenbach, Peter
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Diabetes
- By the university
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Lund University