Search: onr:"swepub:oai:lup.lub.lu.se:cc86e66a-6d1c-4902-9e21-1db77433bb3a" >
Islet Autoimmunity ...
-
Anand, VibhaIBM Thomas J. Watson Research Center
(author)
Islet Autoimmunity and HLA Markers of Presymptomatic and Clinical Type 1 Diabetes : Joint Analyses of Prospective Cohort Studies in Finland, Germany, Sweden, and the U.S
- Article/chapterEnglish2021
Publisher, publication year, extent ...
-
2021-06-23
-
American Diabetes Association,2021
-
8 s.
Numbers
-
LIBRIS-ID:oai:lup.lub.lu.se:cc86e66a-6d1c-4902-9e21-1db77433bb3a
-
https://lup.lub.lu.se/record/cc86e66a-6d1c-4902-9e21-1db77433bb3aURI
-
https://doi.org/10.2337/dc20-1836DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:art swepub-publicationtype
-
Subject category:ref swepub-contenttype
Notes
-
OBJECTIVE: To combine prospective cohort studies, by including HLA harmonization, and estimate risk of islet autoimmunity and progression to clinical diabetes.RESEARCH DESIGN AND METHODS: For prospective cohorts in Finland, Germany, Sweden, and the U.S., 24,662 children at increased genetic risk for development of islet autoantibodies and type 1 diabetes have been followed. Following harmonization, the outcomes were analyzed in 16,709 infants-toddlers enrolled by age 2.5 years.RESULTS: In the infant-toddler cohort, 1,413 (8.5%) developed at least one autoantibody confirmed at two or more consecutive visits (seroconversion), 865 (5%) developed multiple autoantibodies, and 655 (4%) progressed to diabetes. The 15-year cumulative incidence of diabetes varied in children with one, two, or three autoantibodies at seroconversion: 45% (95% CI 40-52), 85% (78-90), and 92% (85-97), respectively. Among those with a single autoantibody, status 2 years after seroconversion predicted diabetes risk: 12% (10-25) if reverting to autoantibody negative, 30% (20-40) if retaining a single autoantibody, and 82% (80-95) if developing multiple autoantibodies. HLA-DR-DQ affected the risk of confirmed seroconversion and progression to diabetes in children with stable single-autoantibody status. Their 15-year diabetes incidence for higher- versus lower-risk genotypes was 40% (28-50) vs. 12% (5-38). The rate of progression to diabetes was inversely related to age at development of multiple autoantibodies, ranging from 20% per year to 6% per year in children developing multipositivity in ≤2 years or >7.4 years, respectively.CONCLUSIONS: The number of islet autoantibodies at seroconversion reliably predicts 15-year type 1 diabetes risk. In children retaining a single autoantibody, HLA-DR-DQ genotypes can further refine risk of progression.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Li, YingIBM Thomas J. Watson Research Center
(author)
-
Liu, BinIBM Thomas J. Watson Research Center
(author)
-
Ghalwash, MohamedAin Shams University,IBM Thomas J. Watson Research Center
(author)
-
Koski, EileenIBM Thomas J. Watson Research Center
(author)
-
Ng, KenneyIBM Thomas J. Watson Research Center
(author)
-
Dunne, Jessica LJuvenile Diabetes Research Foundation
(author)
-
Jönsson, JosefineLund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups,Skåne University Hospital(Swepub:lu)jo7760jo
(author)
-
Winkler, ChristianeTechnical University of Munich,Helmholtz Zentrum München
(author)
-
Knip, MikaelUniversity of Helsinki,Tampere University Hospital,Helsinki University Central Hospital,Folkhälsan Research Center
(author)
-
Toppari, JormaTurku University Hospital,University of Turku
(author)
-
Ilonen, JormaUniversity of Turku,Turku University Hospital
(author)
-
Killian, Michael BPacific Northwest Research Institute
(author)
-
Frohnert, Brigitte IUniversity of Colorado
(author)
-
Lundgren, MarkusHelmholtz Zentrum München(Swepub:lu)med-mn2
(author)
-
Ziegler, Anette-GabrieleTechnical University of Munich,Helmholtz Zentrum München
(author)
-
Hagopian, WilliamPacific Northwest Research Institute
(author)
-
Veijola, RiittaUniversity of Oulu,Oulu University Hospital(Swepub:lu)ri3323ve
(author)
-
Rewers, MarianUniversity of Colorado
(author)
-
IBM Thomas J. Watson Research CenterAin Shams University
(creator_code:org_t)
-
T1DI Study Group
Related titles
-
In:Diabetes Care: American Diabetes Association44, s. 2269-22761935-55480149-5992
Internet link
Find in a library
To the university's database
- By the author/editor
-
Anand, Vibha
-
Li, Ying
-
Liu, Bin
-
Ghalwash, Mohame ...
-
Koski, Eileen
-
Ng, Kenney
-
show more...
-
Dunne, Jessica L
-
Jönsson, Josefin ...
-
Winkler, Christi ...
-
Knip, Mikael
-
Toppari, Jorma
-
Ilonen, Jorma
-
Killian, Michael ...
-
Frohnert, Brigit ...
-
Lundgren, Markus
-
Ziegler, Anette- ...
-
Hagopian, Willia ...
-
Veijola, Riitta
-
Rewers, Marian
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Endocrinology an ...
- Articles in the publication
-
Diabetes Care
- By the university
-
Lund University