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Neutrophil extracel...
Neutrophil extracellular traps in the central nervous system hinder bacterial clearance during pneumococcal meningitis
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- Mohanty, Tirthankar (author)
- Lund University,Lunds universitet,Translationell Sepsisforskning,Forskargrupper vid Lunds universitet,Translational Sepsis research,Lund University Research Groups
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- Fisher, Jane (author)
- Lund University,Lunds universitet,Translationell Sepsisforskning,Forskargrupper vid Lunds universitet,Translational Sepsis research,Lund University Research Groups
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- Bakochi, Anahita (author)
- Lund University,Lunds universitet,Infection Medicine Proteomics,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Neumann, Ariane (author)
- Lund University,Lunds universitet,Molekylär patogenes,Forskargrupper vid Lunds universitet,Molecular Pathogenesis,Lund University Research Groups
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- Cardoso, José Francisco Pereira (author)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Karlsson, Christofer A Q (author)
- Lund University,Lunds universitet,Infection Medicine Proteomics,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Pavan, Chiara (author)
- University of Copenhagen
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- Lundgaard, Iben (author)
- Lund University,Lunds universitet,Glia-Immune Interactions,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Nilson, Bo (author)
- Lund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,SEBRA Sepsis and Bacterial Resistance Alliance,Forskargrupper vid Lunds universitet,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine,Lund University Research Groups,Regional Laboratories Region Skåne
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- Reinstrup, Peter (author)
- Lund University,Lunds universitet,Neurointensivvård,Forskargrupper vid Lunds universitet,Neurosurgical intensive care,Lund University Research Groups
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- Bonnevier, Johan (author)
- Lund University,Lunds universitet,Cirkulationsfysiologi vid kritisk sjukdom,Forskargrupper vid Lunds universitet,Fluid resuscitation in critical illness,Lund University Research Groups
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- Cederberg, David (author)
- Skåne University Hospital
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- Malmström, Johan (author)
- Lund University,Lunds universitet,Infection Medicine Proteomics,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Bentzer, Peter (author)
- Lund University,Lunds universitet,Cirkulationsfysiologi vid kritisk sjukdom,Forskargrupper vid Lunds universitet,Fluid resuscitation in critical illness,Lund University Research Groups,Helsingborg Hospital
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- Linder, Adam (author)
- Lund University,Lunds universitet,Translationell Sepsisforskning,Forskargrupper vid Lunds universitet,Translational Sepsis research,Lund University Research Groups
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(creator_code:org_t)
- 2019-04-10
- 2019
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 1667-1667
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Abstract
Subject headings
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- Neutrophils are crucial mediators of host defense that are recruited to the central nervous system (CNS) in large numbers during acute bacterial meningitis caused by Streptococcus pneumoniae. Neutrophils release neutrophil extracellular traps (NETs) during infections to trap and kill bacteria. Intact NETs are fibrous structures composed of decondensed DNA and neutrophil-derived antimicrobial proteins. Here we show NETs in the cerebrospinal fluid (CSF) of patients with pneumococcal meningitis, and their absence in other forms of meningitis with neutrophil influx into the CSF caused by viruses, Borrelia and subarachnoid hemorrhage. In a rat model of meningitis, a clinical strain of pneumococci induced NET formation in the CSF. Disrupting NETs using DNase I significantly reduces bacterial load, demonstrating that NETs contribute to pneumococcal meningitis pathogenesis in vivo. We conclude that NETs in the CNS reduce bacterial clearance and degrading NETs using DNase I may have significant therapeutic implications.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Mohanty, Tirthan ...
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Fisher, Jane
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Bakochi, Anahita
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Neumann, Ariane
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Cardoso, José Fr ...
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Karlsson, Christ ...
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show more...
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Pavan, Chiara
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Lundgaard, Iben
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Nilson, Bo
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Reinstrup, Peter
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Bonnevier, Johan
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Cederberg, David
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Malmström, Johan
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Bentzer, Peter
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Linder, Adam
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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Nature Communica ...
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Lund University