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Association of an O...
Association of an Osteopontin gene promoter polymorphism with susceptibility to diabetic nephropathy in Asian Indians
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Cheema, Balneek Singh (author)
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Iyengar, Sreenivasa (author)
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- Ahluwalia, Tarun (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Kohli, Harbir Singh (author)
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Sharma, Rajni (author)
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Shah, Viral N. (author)
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Bhansali, Anil (author)
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Sakhuja, V. (author)
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Khullar, Madhu (author)
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(creator_code:org_t)
- Elsevier BV, 2012
- 2012
- English.
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In: Clinica Chimica Acta. - : Elsevier BV. - 0009-8981. ; 413:19-20, s. 1600-1604
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http://dx.doi.org/10...
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Abstract
Subject headings
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- Genetic predisposition has been proposed to be a major determinant in the development of renal complications of diabetes. Osteopontin (OPN) has been suggested to be associated with renal diseases characterized by tubulointerstitial fibrosis and proteinuria. However, information on association of genetic polymorphisms in OPN with diabetic nephropathy is lacking. Thus, the present study was designed with the aim to examine the association of an OPN gene promoter polymorphism with diabetic nephropathy in Asian Indians. OPN C-443T (rs11730582) polymorphism was determined in 1115 type 2 diabetic patients belonging to two independently ascertained cohorts using Real time PCR based Taqman assay. We observed a nearly threefold elevated risk of diabetic nephropathy among carriers of T allele and TT genotype of OPN C-443T polymorphism. Further, this allele was found to be significantly associated with proteinuria and lower eGFR, a hallmark of diabetic nephropathy, in both our cohorts. This is the first study which suggests that OPN C-443T polymorphism may be a significant risk factor for diabetic nephropathy in type 2 diabetic patients. (C) 2012 Elsevier B.V. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Keyword
- Osteopontin
- Genetic polymorphism
- Type 2 diabetes
- Diabetic nephropathy
Publication and Content Type
- art (subject category)
- ref (subject category)
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